David E. Isenman

University of Toronto — Canada

Immunology and Microbiology · Life Sciences

39h-index4.5kcitations102works2.02yr avg
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Research Topics

Complement system in diseases(44), Monoclonal and Polyclonal Antibodies Research(41), Glycosylation and Glycoproteins Research(20), Blood groups and transfusion(15), Erythrocyte Function and Pathophysiology(11)

Publications101 total

A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion
PLoS Pathogens·2025· 3 citedOpen Access
A surface lipoprotein on <i>Pasteurella multocida</i> binds complement factor I to promote immune evasion
2024· 1 citedOpen Access
Neuropilin-1 Acts as a Receptor for Complement Split Products
Frontiers in Immunology·2019· 22 citedOpen Access
Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria
Cell Host & Microbe·2018· 122 citedOpen Access
C4
Elsevier eBooks·2017· 9 cited
List of Contributors
Elsevier eBooks·2017
Complement and Immunoglobulin Biology Leading to Clinical Translation
Elsevier eBooks·2017
Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus
Scientific Reports·2017· 67 citedOpen Access
Notochordal Cell-Based Therapeutics Can Regenerate the Degenerative Disc
The Spine Journal·2016· 1 cited
Ig‐like transcript 4 as a cellular receptor for soluble complement fragment C4d
The FASEB Journal·2015· 31 cited
Regulation of Humoral Immunity by Complement
Immunity·2012· 386 citedOpen Access
Complement C5 - eScholarship
2012
A Crystal Structure of the Complex Between Human Complement Receptor 2 and Its Ligand C3d
Science·2011· 85 cited
Dual interaction of factor H with C3d and glycosaminoglycans in host–nonhost discrimination by complement
Proceedings of the National Academy of Sciences·2011· 221 cited
Immune Evasion of <i>Moraxella catarrhalis</i> Involves Ubiquitous Surface Protein A-Dependent C3d Binding
The Journal of Immunology·2011· 29 citedOpen Access
Structure of Factor H domains 19-20 in complex with complement C3d
2010
A new possible mechanism for target discrimination of the alternative pathway revealed by structural and functional studies of factor H domains 19–20 and C3d
Molecular Immunology·2010
Mutational Analyses Reveal that the Staphylococcal Immune Evasion Molecule Sbi and Complement Receptor 2 (CR2) Share Overlapping Contact Residues on C3d: Implications for the Controversy Regarding the CR2/C3d Cocrystal Structure
The Journal of Immunology·2010· 40 cited
Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome
Journal of Biological Chemistry·2009· 93 citedOpen Access
The FGL2‐FcγRIIB pathway: A novel mechanism leading to immunosuppression
European Journal of Immunology·2008· 98 citedOpen Access
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Frequent Co-authors

R. H. Painter(7), Keith J. Dorrington(6), Elisa Leung(5), Jean van den Elsen(5), Michael C. Carroll(4), Marc J. Shulman(4), Neil R. Cooper(3), Stefan Bagby(3), Aiko Taniguchi‐Sidle(3), John R. Young(2), Markus J. Lehtinen(2), T. Sakari Jokiranta(2), Russell J. Diefenbach(2), D. I. C. Kells(2), Julia D. Burman(2), Stefan Spycher(2), Sudha Arya(2), Alberto Martín(2), Liliana Clemenza(2), Edward L.G. Pryzdial(2)