Lee Techner

Tsumura Research Institute (Japan) — Japan

Medicine · Health Sciences

18h-index2.0kcitations35works0.02yr avg
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Research Topics

Enhanced Recovery After Surgery(25), Cardiac, Anesthesia and Surgical Outcomes(24), Anesthesia and Pain Management(19), Gastrointestinal motility and disorders(4), Nausea and vomiting management(4)

Publications35 total

Evaluation of TU-100 (Daikenchuto), a Traditional Japanese Kampo Medicine, as an Adjunct to Enhanced Recovery After Surgery, for Acceleration of Gastrointestinal Recovery After Bowel Resection: Results of a Proof-of-Concept, Phase 2, Randomized, Double-Blinded, Placebo-Controlled Trial
Diseases of the Colon & Rectum·2025Open Access
Alvimopan Accelerates Gastrointestinal Recovery After Radical Cystectomy: A Multicenter Randomized Placebo-Controlled Trial
European Urology·2014· 214 cited
Alvimopan, a Peripherally Acting μ-Opioid Receptor Antagonist, is Associated with Reduced Costs after Radical Cystectomy: Economic Analysis of a Phase 4 Randomized, Controlled Trial
The Journal of Urology·2013· 67 cited
1870 ALVIMOPAN, A PERIPHERALLY ACTING MU-OPIOID RECEPTOR ANTAGONIST, ACCELERATES GASTROINTESTINAL RECOVERY AND DECREASES LENGTH OF HOSPITAL STAY AFTER RADICAL CYSTECTOMY
The Journal of Urology·2013· 4 cited
Economic Analysis of Alvimopan—A Clarification and Commentary
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy·2012· 1 citedOpen Access
Alvimopan for acceleration of GI recovery after bowel resection.
PubMed·2012
Mo2084 CB-5945 0.25 mg Twice Daily Is Associated With Significantly Increased Spontaneous Bowel Movement and Greater Proportion of Responders Compared With Placebo in Patients on Chronic Opioid Therapy for Noncancer Pain (45CL242; NCT01207427)
Gastroenterology·2012· 7 citedOpen Access
ADL5945, a potent orally bioavailable peripheral opioid receptor antagonist, improves bowel motility w/a low incidence/severity of GI AEs in a dose-dependent manner: results of 2 Ph 2 trials in opioid-induced constipation pts (45CL242 and 45CL243)
Journal of Pain·2012· 3 cited
Evaluation of Clinical Outcomes With Alvimopan in Clinical Practice
Annals of Surgery·2012· 51 cited
Impact of alvimopan (entereg) on hospital costs after bowel resection: results from a large inpatient database.
PubMed·2011· 23 citedOpen Access
Alvimopan for the Management of Postoperative Ileus After Bowel Resection: Characterization of Clinical Benefit by Pooled Responder Analysis
World Journal of Surgery·2010· 46 citedOpen Access
On “Pathogenesis and Management of Postoperative Ileus” (Clin Colon Rectal Surg 2009;22:47–50)
Clinics in Colon and Rectal Surgery·2010· 2 citedOpen Access
The Impact of Alvimopan on Hospital Cost After Bowel Resection: Results From a Large Inpatient Database
2010· 1 cited
Gastrointestinal recovery after laparoscopic colectomy: results of a prospective, observational, multicenter study
Surgical Endoscopy·2009· 84 cited
Economic analysis of alvimopan in North American Phase III efficacy trials
American Journal of Health-System Pharmacy·2009· 58 cited
The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor
Pharmacology & Therapeutics·2007· 67 cited
Alvimopan accelerates gastrointestinal recovery after bowel resection regardless of age, gender, race, or concomitant medication use
Surgery·2007· 33 cited
Effect of alvimopan (ALV) on gastrointestinal (GI) recovery, length of hospital stay (LOS), and postoperative ileus (POI)-related morbidity in patients (PTS) undergoing bowel resection (BR) for colon or rectal cancer (CRC)
Journal of Clinical Oncology·2007· 5 cited
Patterns of Gastrointestinal Recovery after Bowel Resection and Total Abdominal Hysterectomy: Pooled Results from the Placebo Arms of Alvimopan Phase III North American Clinical Trials
Journal of the American College of Surgeons·2007· 58 cited
Postoperative Ileus-Related Morbidity Profile in Patients Treated with Alvimopan after Bowel Resection
Journal of the American College of Surgeons·2007· 66 cited
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Frequent Co-authors

Wei Du(14), Conor P. Delaney(9), K. Gabriel(7), Eugene R. Viscusi(7), Bruce G. Wolff(6), Bruce A. Wallin(6), Anthony J. Senagore(6), B. Wallin(5), John G. Fort(5), Sara Poston(5), Fabrizio Michelassi(3), James L. Weese(3), Joel J. Bauer(3), W. Schmidt(3), Ashish M. Kamat(3), Gilad E. Amiel(3), Timothy L. Beard(3), Amr Fergany(3), Wade J. Sexton(3), Joel W. Slaton(3)