Eric A. Sobie

Icahn School of Medicine at Mount Sinai — United States

Medicine · Health Sciences

41h-index5.9kcitations349works2.72yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(136), Ion channel regulation and function(84), Neuroscience and Neural Engineering(52), Receptor Mechanisms and Signaling(33), Neuroscience and Neuropharmacology Research(12)

Publications349 total

predicTox: an integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs
Database·2026Open Access
Combine the wet and dry ingredients: Mixing experimental and computational models for a deeper understanding of stem cell‐derived cardiomyocytes
The Journal of Physiology·2025· 1 citedOpen Access
Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data".
PubMed·2025Open Access
Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data
Molecular & Cellular Proteomics·2025Open Access
Creating Cell-specific Computational Models of Stem Cell-derived Cardiomyocytes Using Optical Experiments
2025
Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber Fate
2024· 2 citedOpen Access
Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments
PLoS Computational Biology·2024· 5 citedOpen Access
Multiscale mapping of transcriptomic signatures for cardiotoxic drugs
Nature Communications·2024· 10 citedOpen Access
Abstract We014: Creating Cell-specific Computational Models of Stem Cell-derived Cardiomyocytes Using Optical Experiments
Circulation Research·2024
Cell-to-cell heterogeneity in ion channel conductance impacts substrate vulnerability to arrhythmia
American Journal of Physiology-Heart and Circulatory Physiology·2024· 4 citedOpen Access
<i>HRAS</i> -Mutant Cardiomyocyte Model of Multifocal Atrial Tachycardia
Circulation Arrhythmia and Electrophysiology·2024· 4 citedOpen Access
Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments
2024· 6 citedOpen Access
A computational model calibration pipeline for predicting electrophysiological variation in human stem cell-derived cardiomyocytes
2023
Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors
Frontiers in Pharmacology·2023· 12 citedOpen Access
Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients
Trends in Pharmacological Sciences·2023· 5 citedOpen Access
Modeling the spatiotemporal properties of crosstalk between RYR and IP3R-mediated Ca2+release in failing cardiomyocytes
Biophysical Journal·2023· 1 cited
Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models
PLoS Computational Biology·2022· 12 citedOpen Access
Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation
Stem Cell Research & Therapy·2022· 6 citedOpen Access
Quantitative approaches to drug safety: The 2022 <scp>PSP</scp> special issue
CPT Pharmacometrics & Systems Pharmacology·2022Open Access
Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue Models
2022· 5 citedOpen Access
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Frequent Co-authors

W. Jonathan Lederer(8), M. Saleet Jafri(7), Long‐Sheng Song(5), Ravi Iyengar(5), Evren U. Azeloglu(5), Marc R. Birtwistle(4), George S.B. Williams(4), Sílvia Guatimosim(4), W. Jonathan Lederer(3), Avi Ma’ayan(3), Clive N. Svendsen(3), Leslie Tung(3), Amrita X. Sarkar(3), David J. Christini(3), Gomathi Jayaraman(3), Rafael Dariolli(3), Christine Falce(3), Gregory D. Smith(3), Sherry L. Jenkins(2), Denis Torre(2)