Frédéric Y. Bois

Université Paris-Seine — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index9.6kcitations359works3.62yr avg
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Research Topics

Carcinogens and Genotoxicity Assessment(52), Statistical Methods in Clinical Trials(43), Effects and risks of endocrine disrupting chemicals(38), Nicotinic Acetylcholine Receptors Study(35), Computational Drug Discovery Methods(34)

Publications359 total

Assessing hepatic impairment with biomarker-informed physiologically based pharmacokinetic modeling: Strengths and limitations of the endogenous biomarker Coproporphyrin I
Drug Metabolism and Disposition·2025
Corrigendum to “radiation dosimetry of the 18 kDa translocator protein ligand [18F]PBR111 in humans” [nuclear medicine and biology, 144–145 (2025); 109,011]
Nuclear Medicine and Biology·2025
Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge
Regulatory Toxicology and Pharmacology·2025· 1 citedOpen Access
Using the Simcyp R Package for <scp>PBPK</scp> Simulation Workflows With the Simcyp Simulator
CPT Pharmacometrics & Systems Pharmacology·2025Open Access
Radiation dosimetry of the 18 kDa translocator protein ligand [18F]PBR111 in humans
Nuclear Medicine and Biology·2025· 1 citedOpen Access
Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for <i>In Vitro</i> Release Testing: Development and Validation
ACS Applied Bio Materials·2024· 10 citedOpen Access
Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework
Pharmaceutics·2024· 6 citedOpen Access
Beyond Time-Homogeneity for Continuous-Time Multistate Markov Models
Journal of Computational and Graphical Statistics·2024· 2 citedOpen Access
A Bayesian framework for virtual comparative trials and bioequivalence assessments
Frontiers in Pharmacology·2024· 5 citedOpen Access
A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator
CPT Pharmacometrics & Systems Pharmacology·2024· 10 citedOpen Access
Harnessing the power of IVIVE-PBPK to explore potential discordance between local gut vs systemic bioequivalence in health and disease: the case of budesonide in crohn’s disease
Drug Metabolism and Pharmacokinetics·2024
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors
Environmental Health Perspectives·2024· 12 citedOpen Access
Characterization of human variability in cellular stress response transcriptomic perturbations upon chemical exposure in PBMCs
Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)·2024
Virtual Trial Comparisons and Bioequivalence Assessment: From Data-Based to Probabilistic Assessment
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Virtual Trial Comparisons and Bioequivalence Assessment: From Data-Based to Probabilistic Assessment
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Virtual Trial Comparisons and Bioequivalence Assessment: From Data-Based to Probabilistic Assessment
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Virtual Trial Comparisons and Bioequivalence Assessment: From Data-Based to Probabilistic Assessment
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
CEC02-06: Demonstration of PBK model evaluations: Case studies in fish species and farm animals
Toxicology Letters·2023
S15-02: EFSA Modelling tools for human health, animal health and ecological risk assessment
Toxicology Letters·2023
Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling
Pharmaceutics·2023· 13 citedOpen Access
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Frequent Co-authors

Lauren Zeise(7), George Loizou(6), Kelly Cosgrove(6), Ursula Gundert‐Remy(5), Irina Esterlis(5), John Seibyl(5), Céline Brochot(5), Jos Bessems(4), Sandra Coecke(4), Sofia Batista Leite(4), Emanuela Testai(4), Paul Jennings(4), Julie K. Staley(4), Weihsueh A. Chiu(4), Thomas N. Tozer(4), W. Dekant(3), Alice Limonciel(3), Harvey J. Clewell(3), Gilles Tamagnan(3), Christopher J. Portier(3)