Debbie K. Ledezma

University of California, San Diego — United States

Engineering · Physical Sciences

6h-index172citations16works0.72yr avg
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Research Topics

Nanoplatforms for cancer theranostics(8), Immunotherapy and Immune Responses(3), RNA Interference and Gene Delivery(3), Neuroblastoma Research and Treatments(3), Cancer, Hypoxia, and Metabolism(2)

Publications16 total

879 Local delivery of a plant virus immunotherapy with irreversible electroporation elicits dendritic cell activation and CD8 T cell infiltration in an orthotopic PDAC tumor model
Regular and Young Investigator Award Abstracts·2025Open Access
Irreversible electroporation with intratumoral plant virus immunotherapy induces systemic immunity in a metastatic model of pancreatic cancer
Cancer Letters·2025Open Access
A cowpea mosaic virus adjuvant conjugated to liposomes loaded with tumor cell lysates as an ovarian cancer vaccine
Nature Communications·2025· 3 citedOpen Access
Irreversible Electroporation with Intratumoral Plant Virus Immunotherapy Induces Systemic Immunity in an Orthotopic Model of Pancreatic Cancer
SSRN Electronic Journal·2025Open Access
1127 Virus nanoparticle intratumoral vaccines for HER2+ malignancies
Regular and Young Investigator Award Abstracts·2024Open Access
1113 Engineering vaccines against S100A9 to treat cancer co-morbidities
Regular and Young Investigator Award Abstracts·2024Open Access
Photothermal therapy co-localized with CD137 agonism improves survival in an SM1 melanoma model without hepatotoxicity
Nanomedicine·2024· 2 citedOpen Access
PolyIC-Coated Prussian Blue Nanoparticles As a Dual-Mode HIV Latency Reversing Agent
Nanomedicine·2022· 1 citedOpen Access
Review for "Micelle encapsulation zinc‐doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair"
2022
Interstitial Photothermal Therapy Generates Durable Treatment Responses in Neuroblastoma
Advanced Healthcare Materials·2022· 20 citedOpen Access
Anti-Fn14-Conjugated Prussian Blue Nanoparticles as a Targeted Photothermal Therapy Agent for Glioblastoma
Nanomaterials·2022· 15 citedOpen Access
The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells
Cancers·2022· 13 citedOpen Access
CD137 agonist potentiates the abscopal efficacy of nanoparticle-based photothermal therapy for melanoma
Nano Research·2021· 30 citedOpen Access
CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma
Translational Oncology·2020· 51 citedOpen Access
Indocyanine Green-Nexturastat A-PLGA Nanoparticles Combine Photothermal and Epigenetic Therapy for Melanoma
Nanomaterials·2020· 37 citedOpen Access
Combined Nanoparticle-based Photothermal Therapy and Epigenetic Immunomodulation for Melanoma
2019

Frequent Co-authors

Rohan Fernandes(9), Preethi B. Balakrishnan(6), Nicole F. Steinmetz(6), Juliana Cano‐Mejia(3), Anshi Shukla(3), Elizabeth E. Sweeney(3), Kim Nguyen-Ta(3), Himangshu Sonowal(3), Hana M. Russo(3), Isabel G. Newton(3), Rebekah R. White(3), Erica Palmer(2), Alejandro Villagra(2), Catherine M. Bollard(2), Jacob A. Medina(2), Jie Chen(2), Jessica Fernanda Affonso de Oliveira(2), Melissa Hadley(1), Jaclyn Andricovich(1), Vishal Patel(1)