Kurt E. Amrein

Roche (Switzerland) — Switzerland

Medicine · Health Sciences

27h-index3.5kcitations46works131.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(11), T-cell and B-cell Immunology(6), Cell Adhesion Molecules Research(5), Hormonal Regulation and Hypertension(5), Protein Tyrosine Phosphatases(5)

Publications46 total

Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter
Nature·2024· 2 citedOpen Access
A novel antibiotic class targeting the lipopolysaccharide transporter
Nature·2024· 260 citedOpen Access
Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors
Journal of Medicinal Chemistry·2020· 20 citedOpen Access
How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study
Biochimica et Biophysica Acta (BBA) - Biomembranes·2020· 13 citedOpen Access
Machine learning-powered antibiotics phenotypic drug discovery
Scientific Reports·2019· 109 citedOpen Access
Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2)
Hypertension·2016· 97 citedOpen Access
Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)
Organic & Biomolecular Chemistry·2016· 29 cited
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys
Journal of Medicinal Chemistry·2015· 42 citedOpen Access
Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases
CHIMIA International Journal for Chemistry·2015· 1 citedOpen Access
CCDC 1415366: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
White-to-brown metabolic conversion of human adipocytes by JAK inhibition
Nature Cell Biology·2014· 184 citedOpen Access
11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects
Journal of Clinical Investigation·2013· 127 citedOpen Access
An inflammatory micro-environment promotes human adipocyte apoptosis
Molecular and Cellular Endocrinology·2011· 56 citedOpen Access
Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)
Journal of Biological Chemistry·2011· 45 citedOpen Access
THP-1 Macrophages and SGBS Adipocytes ? A New Human in vitro Model System of Inflamed Adipose Tissue
Frontiers in Endocrinology·2011· 36 citedOpen Access
Abstract 10854: Aleglitazar, a Balanced Dual PPAR alpha/ gamma Agonist, Decreases Lipolysis and Cytokine Production in a Cellular Model of Inflamed Human Adipose Tissue.
Circulation·2010· 4 cited
P78 Elimination of acute drug side effects without loss of efficacy by site-specific PEGylation of insulin-like growth factor I
Growth Hormone & IGF Research·2010
11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ and is stimulated by extracellular glucose
Molecular and Cellular Endocrinology·2008· 62 cited
An improved vector system for insertional gene inactivation inspired by the tmRNA-tagging system of S. pneumoniae
Journal of Microbiological Methods·2000· 3 cited
Microarray-Based Identification of a Novel <i>Streptococcus pneumoniae</i> Regulon Controlled by an Autoinduced Peptide
Journal of Bacteriology·2000· 238 citedOpen Access
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Frequent Co-authors

Nicholas Flint(9), Paul Burn(9), Bartholomew M. Sefton(5), Juliette Molnos(5), A. Mayweg(5), P Burn(4), Sannah Zoffmann(4), Kenneth A. Bradley(4), Martin Gassmann(4), Anna Dzyakanchuk(4), Johannes D. Aebi(4), Bernd Kuhn(4), Hans Peter Märki(4), Andréy S. Shaw(3), Christoph Bieniossek(3), Roland Lange(3), B Panholzer(3), Michaela Keuper(3), Martin Wabitsch(3), Pamela Fischer‐Posovszky(3)