Ronan Depoortère

Neurolixis (United States) — United States

Neuroscience · Life Sciences

34h-index3.5kcitations101works2.42yr avg
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Research Topics

Neurotransmitter Receptor Influence on Behavior(66), Neuroscience and Neuropharmacology Research(40), Receptor Mechanisms and Signaling(36), Stress Responses and Cortisol(12), Treatment of Major Depression(12)

Publications101 total

The 5-HT <sub>1A</sub> receptor selective agonist NLX-204 displays analgesic activity in the knee osteoarthritis and plantar incisional post-operative pain models in rats
2025
NLX-112 is anti-inflammatory, upregulates GDNF and is neuroprotective against MPTP-induced nigrostriatal dopaminergic degeneration in mice
2025Open Access
The selective 5-HT <sub>1A</sub> receptor biased agonist, NLX-101, corrects anomalous behavioral phenotype in a mouse model of Fragile X syndrome
2025Open Access
The antidepressant-like activity of ketamine in the rat chronic mild stress model requires activation of cortical 5-HT1A receptors
Behavioural Pharmacology·2024· 2 cited
Pharmacodynamic, pharmacokinetic and rat brain receptor occupancy profile of NLX-112, a highly selective 5-HT1A receptor biased agonist
Naunyn-Schmiedeberg s Archives of Pharmacology·2024· 1 citedOpen Access
Fentanyl dose-sparing in polyarthritic rats requires full agonism at 5-HT1A receptors: Comparison between NLX-112, (±)8-OH-DPAT, and buspirone
Journal of Opioid Management·2024· 2 cited
The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, like ketamine, elicit rapid-acting antidepressant activity in the rat chronic mild stress model via cortical mechanisms
Journal of Psychopharmacology·2024· 12 cited
The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models
Psychopharmacology·2023· 12 citedOpen Access
Ketamine and the 5-HT1A receptor biased agonists, NLX-204 and NLX-101, share common cortical efficacious rapid acting antidepressant mechanisms in rat cms depression model
Neuroscience Applied·2023Open Access
Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia
NeuroImage Clinical·2023· 6 citedOpen Access
The 5-HT1A receptor biased agonist, NLX-204, shows rapid-acting antidepressant-like properties and neurochemical changes in two mouse models of depression
Behavioural Brain Research·2022· 11 citedOpen Access
Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice
Molecular Psychiatry·2022· 16 citedOpen Access
NLX-112, a highly selective 5-HT1A receptor biased agonist, does not exhibit misuse potential in male rats or macaques
Neuropharmacology·2022· 3 citedOpen Access
Dissecting the contribution of 5-HT1A auto- and heteroreceptors in sucrose overconsumption in mice
Biomedicine & Pharmacotherapy·2022· 5 citedOpen Access
P.0604 Similarly to ketamine, selective cortical 5-HT1A receptor biased agonists elicit rapid-acting antidepressant effects in the rat chronic mild stress model
European Neuropsychopharmacology·2021· 3 cited
The selective 5-HT1A receptor agonist NLX-112 displays anxiolytic-like activity in mice
Naunyn-Schmiedeberg s Archives of Pharmacology·2021· 10 cited
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders
Pharmacology & Therapeutics·2021· 76 citedOpen Access
NLX-101, a cortical 5-HT1A receptor biased agonist, reverses scopolamine-induced deficit in the delayed non-matching to position model of cognition
Brain Research·2021· 12 cited
NLX-101, a highly selective 5-HT1A receptor biased agonist, mediates antidepressant-like activity in rats via prefrontal cortex 5-HT1A receptors
Behavioural Brain Research·2020· 17 cited
Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT&lt;sub&gt;1A&lt;/sub&gt; Receptor Biased Agonists
Pharmacology·2020· 6 cited
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Frequent Co-authors

Adrian Newman‐Tancredi(28), Laurent Bardin(18), Agnès L. Auclair(13), Ghislaine Perrault(10), D. J. Sanger(9), Mark S. Kleven(8), Denis Boulay(5), Mark A. Varney(5), B. Scatton(4), Guy Griebel(4), Françis C. Colpaert(4), Bernard Vacher(4), Didier Cussac(3), M. W. Emmett‐Oglesby(3), Wouter Koek(3), Gh. Perrault(3), Guy Sandner(3), Georges Di Scala(3), Joël Besnard(3), M. Decobert(2)