Xerardo García‐Mera

Universidade de Santiago de Compostela — Spain

Materials Science · Physical Sciences

26h-index2.4kcitations277works1.12yr avg
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Research Topics

Crystallization and Solubility Studies(63), X-ray Diffraction in Crystallography(63), Computational Drug Discovery Methods(42), HIV/AIDS drug development and treatment(31), Chemical Synthesis and Analysis(31)

Publications277 total

CCDC 2094818: Experimental Crystal Structure Determination
The Cambridge Structural Database·2026Open Access
Discovery of first-in-class melanostatin-based ago-allosteric modulators of the dopamine D2 receptors
Biomedicine & Pharmacotherapy·2026Open Access
Conformational Restriction of Designer Drugs Reveals Subtype-Selective and Biased CB<sub>2</sub> Agonists with Neuroprotective Effects
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D <sub>2</sub> Receptors
ACS Medicinal Chemistry Letters·2025· 1 citedOpen Access
Telescoped One-Pot Strategy for the Assembly of <i>cis</i>-4-Hydroxy-<scp>l</scp>-Prolyl Amides
ACS Sustainable Chemistry & Engineering·2024· 1 cited
Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
Biomedicine & Pharmacotherapy·2024· 3 citedOpen Access
Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines
European Journal of Medicinal Chemistry·2024· 2 citedOpen Access
Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity
RSC Medicinal Chemistry·2024· 1 citedOpen Access
Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D<sub>2</sub> Receptors
ACS Medicinal Chemistry Letters·2023· 6 citedOpen Access
Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs
Biomedicine & Pharmacotherapy·2023· 14 citedOpen Access
Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences
ACS Chemical Neuroscience·2023· 17 citedOpen Access
Exploring Structural Determinants of Neuroprotection Bias on Novel Glypromate Bioconjugates with Bioactive Amines
SSRN Electronic Journal·2023Open Access
Exploring the Effect of Halogenation in a Series of Potent and Selective A<sub>2B</sub> Adenosine Receptor Antagonists
Journal of Medicinal Chemistry·2022· 16 citedOpen Access
A<sub>2B</sub> adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Journal for ImmunoTherapy of Cancer·2022· 29 citedOpen Access
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A<sub>1</sub> Antagonists
Journal of Medicinal Chemistry·2022· 11 citedOpen Access
Exploring Non-orthosteric Interactions with a Series of Potent and Selective A<sub>3</sub> Antagonists
ACS Medicinal Chemistry Letters·2022· 4 citedOpen Access
Isolation and structural characterization of stable carbamic–carbonic anhydrides: an experimental and computational study
Organic Chemistry Frontiers·2022· 2 citedOpen Access
Constrained Glypromate&amp;lt;sup&amp;gt;®&amp;lt;/sup&amp;gt; analogues incorporating a bicyclic proline surrogate
Proceedings of 7th International Electronic Conference on Medicinal Chemistry·2021Open Access
Exploring the bioisosterism of proline residue in melanostatin neuropeptide using heteroaromatic scaffolds
Proceedings of 7th International Electronic Conference on Medicinal Chemistry·2021Open Access
Using aza-proline for the assembly of a melanostatin aza-peptide derivative
Proceedings of 7th International Electronic Conference on Medicinal Chemistry·2021Open Access
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Frequent Co-authors

Olga Caamaño(20), Humberto González‐Díaz(19), José E. Rodríguez‐Borges(18), Francisco Prado-Prado(12), Eddy Sotelo(12), Jhonny Azuaje(11), José Brea(11), Franco Fernández(11), Matilde Yáñez(10), Marı́a Isabel Loza(10), Hugo Gutiérrez‐de‐Terán(9), Nerea Alonso(8), María Majellaro(6), Abdelaziz El Maatougui(5), M. Natália D. S. Cordeiro(5), Rubén Prieto‐Díaz(5), M.L.C. Vale(5), Cristian R. Munteanu(4), Francisco Romero-Durán(4), Marı́a Isabel Cadavid(4)