Shigehiko Mizutani

Nagoya University — Japan

Medicine · Health Sciences

46h-index6.7kcitations273works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Peptidase Inhibition and Analysis(70), Pregnancy and preeclampsia studies(41), Neuropeptides and Animal Physiology(38), Neonatal Respiratory Health Research(30), Gestational Trophoblastic Disease Studies(30)

Publications270 total

Optimization of linker sequence of aminopeptidase A-Fc fusion proteins in pharmacokinetics and antihypertensive effect
Drug Metabolism and Pharmacokinetics·2025
Editorial Expression of Concern: P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling
BMC Cancer·2025Open Access
The Fate of Angiotensin II in Placental Tissue and Blood
Hormone and Metabolic Research·2023
The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset
European Journal of Obstetrics & Gynecology and Reproductive Biology X·2023· 4 citedOpen Access
Crosstalk between foetal vasoactive peptide hormones and placental aminopeptidases regulates placental blood flow: Its significance in preeclampsia
Placenta·2022· 9 cited
Placental Leucine Aminopeptidase as a Potential Specific Urine Biomarker for Invasive Ovarian Cancer
Journal of Clinical Medicine·2021· 5 citedOpen Access
Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles
International Journal of Molecular Sciences·2021· 9 citedOpen Access
New insights into human endometrial aminopeptidases in both implantation and menstruation
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2019· 23 citedOpen Access
Are antihypertensives pro or con for pathophysiology of preeclampsia?
Clinical Obstetrics Gynecology and Reproductive Medicine·2019· 1 citedOpen Access
New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor
Expert Opinion on Investigational Drugs·2013· 6 cited
Cystinyl Aminopeptidase/Oxytocinase
Handbook of Proteolytic Enzymes·2012· 5 cited
Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension
International Journal of Hypertension·2012· 32 citedOpen Access
Placental Leucine Aminopeptidase‐ and Aminopeptidase A‐Deficient Mice Offer Insight concerning the Mechanisms Underlying Preterm Labor and Preeclampsia
BioMed Research International·2010· 16 citedOpen Access
A new approach regarding the treatment of preeclampsia and preterm labor
Life Sciences·2010· 19 cited
939 Participant Feedback From the Japanese Version of the Neonatal Resuscitation Program (Neonatal Cardiopulmonary Resuscitation: NCPR Course)
Pediatric Research·2010Open Access
The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells
Cancer Science·2009· 26 citedOpen Access
Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: possible relation to preeclampsia and preterm delivery
Expert Opinion on Medical Diagnostics·2009· 5 cited
In Vitro Degradation of Opioid Peptides by Human Placental Aminopeptidase M
Experimental and Clinical Endocrinology & Diabetes·2009· 19 cited
Oxytocin hypersensitivity in pregnant P-LAP deficient mice
Life Sciences·2009· 10 cited
Liquid chromatography–tandem mass spectrometric method for determination of salivary 17α-hydroxyprogesterone: A noninvasive tool for evaluating efficacy of hormone replacement therapy in congenital adrenal hyperplasia
Journal of Chromatography B·2008· 43 cited
page 1 of 14Next →

Frequent Co-authors

Fumitaka Kikkawa(23), Kiyosumi Shibata(19), Kazuhiko Ino(17), Hiroaki Kajiyama(15), Masafumi Tsujimoto(9), Akira Hattori(7), Seiji Nomura(7), Yutaka Tomoda(6), Tetsuro Nagasaka(5), Hiroshi Nakazato(4), Takahiro Suzuki(4), Akihiro Nawa(4), Mayumi Okada(4), Tomohiro Rogi(3), Mitsuaki Ito(3), Mikio Terauchi(3), Akira Iwase(3), Atsuo Itakura(3), Yasutaka Murata(3), Kazuhiko Ino(3)