Vihandha O. Wickramasinghe

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index2.8kcitations30works50.32yr avg
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Research Topics

RNA Research and Splicing(25), RNA modifications and cancer(13), RNA and protein synthesis mechanisms(9), Nuclear Structure and Function(9), RNA regulation and disease(6)

Publications30 total

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Molecular Cell·2025· 16 cited
Prediction of m6A and m5C at single-molecule resolution reveals a transcriptome-wide co-occurrence of RNA modifications
Nature Communications·2024· 95 citedOpen Access
Publisher Correction: Nuclear export of circular RNA
Nature·2024Open Access
Nuclear export of circular RNA
Nature·2024· 90 cited
Prediction of m6A and m5C at single-molecule resolution reveals a cooccurrence of RNA modifications across the transcriptome
2022· 21 citedOpen Access
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma
Nature Communications·2022· 27 citedOpen Access
Pathogenic variants in nucleoporin <i>TPR (translocated promoter region, nuclear basket protein)</i> cause severe intellectual disability in humans
Human Molecular Genetics·2021· 12 citedOpen Access
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
Molecular Cell·2021· 157 citedOpen Access
Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP
Nature Structural & Molecular Biology·2021· 1 citedOpen Access
RNA in cancer
Nature reviews. Cancer·2020· 1.2k cited
Author Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP
Nature Structural & Molecular Biology·2020· 1 citedOpen Access
Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice
Blood Advances·2020· 8 citedOpen Access
A systems view of spliceosomal assembly and branchpoints with iCLIP
Nature Structural & Molecular Biology·2019· 41 citedOpen Access
Adaptive post-transcriptional reprogramming of metabolism limits response to targeted therapy in BRAF <sup>V600</sup> melanoma
2019· 1 citedOpen Access
Complex-centric proteome profiling by SEC-SWATH-MS
Molecular & Cellular Proteomics·2019
Transcriptome-wide profiling of mammalian spliceosome and branchpoints with iCLIP
2018· 2 cited
A systems view of spliceosomal assembly and branchpoints with iCLIP
2018· 2 citedOpen Access
Regulatory Potential of the RNA Processing Machinery: Implications for Human Disease
Trends in Genetics·2018· 40 cited
Nuclear export of RNA: Different sizes, shapes and functions
Seminars in Cell and Developmental Biology·2017· 63 cited
Impact of Alternative Splicing on the Human Proteome
Cell Reports·2017· 190 citedOpen Access
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Frequent Co-authors

Ashok R. Venkitaraman(10), Ronald A. Laskey(8), Christopher R. Sibley(6), Jernej Ule(6), Kirstyn T. Carey(6), Tobias Williams(5), Murray Stewart(5), David Perera(5), Michael Briese(5), Nejc Haberman(5), Anob M. Chakrabarti(5), Zhen Wang(5), Nicholas M. Luscombe(5), Christopher W. J. Smith(5), Tomaž Curk(5), Linh H. Ngo(4), Julian König(4), Gregory J. Goodall(3), Anthony D. Mills(3), Yoshinori Takei(3)