Jeff L. Ellsworth

Medicine · Health Sciences

25h-index2.9kcitations53works0.02yr avg
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Research Topics

Cholesterol and Lipid Metabolism(8), Lipid metabolism and biosynthesis(7), Virus-based gene therapy research(6), Monoclonal and Polyclonal Antibodies Research(5), Fibroblast Growth Factor Research(5)

Publications53 total

Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS
Molecular Therapy — Methods & Clinical Development·2022· 5 citedOpen Access
AAVHSCs, a Nuclease-Independent Approach for Transduction in Non-human Primate Brain and Retina and Editing of Retinal Cells in Human Organotypic Explants
2021
Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15
PLoS ONE·2020· 12 citedOpen Access
Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH
Molecular Therapy — Methods & Clinical Development·2020· 29 citedOpen Access
AAVHSC characterization for developing treatments for human genetic diseases of the nervous system
Molecular Genetics and Metabolism·2020
Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
PLoS ONE·2019· 25 citedOpen Access
AAVHSCs target multiple cell types in the eye and have potential to treat rare retinal diseases
Investigative Ophthalmology & Visual Science·2019Open Access
Single intravenous dose of AAVHSC15 vector with human phenylalanine hydroxylase transgene results in sustained correction of phenylketonuria in the PAH mouse model
Molecular Genetics and Metabolism·2019
Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing
Proceedings of the National Academy of Sciences·2018· 33 cited
Low Seroprevalence of Neutralizing Antibodies Targeting Two Clade F AAV in Humans
Human Gene Therapy Clinical Development·2018· 13 cited
Low Seroprevalence of Neutralizing Antibodies Targeting Two Clade F AAV in Humans
Human Gene Therapy Clinical Development·2018
Crystal Structure of Fcγ Receptor I and Its Implication in High Affinity γ-Immunoglobulin Binding
Journal of Biological Chemistry·2011· 88 citedOpen Access
Crystal structure of Fc gamma receptor I and its implication in high affinity gamma-immunoglobulin binding.
Journal of Biological Chemistry·2011· 11 cited
B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin
Arthritis Research & Therapy·2010· 99 citedOpen Access
Generation of a high-affinity Fc  receptor by Ig-domain swapping between human CD64A and CD16A
Protein Engineering Design and Selection·2010· 5 citedOpen Access
Recombinant Soluble Human FcγR1A (CD64A) Reduces Inflammation in Murine Collagen-Induced Arthritis
The Journal of Immunology·2009· 30 cited
73 RECOMBINANT HUMAN FIBROBLAST GROWTH FACTOR 18 AS THERAPY FOR OSTEOARTHRITIS: A DOG MENISCECTOMY MODEL STUDY
Osteoarthritis and Cartilage·2008· 1 cited
Targeting Immune Complex-Mediated Hypersensitivity with Recombinant Soluble Human FcγRIA (CD64A)
The Journal of Immunology·2008· 30 citedOpen Access
Use of Adenovirus-Mediated Gene Transfer to Facilitate Biological Annotation of Novel Genes
Humana Press eBooks·2007
80 THERAPEUTIC EFFECTS OF FIBROBLAST GROWTH FACTOR-18 IN A RAT MODEL OF ESTABLISHED OSTEOARTHRITIS
Osteoarthritis and Cartilage·2007· 1 citedOpen Access
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Frequent Co-authors

Albert Seymour(8), A D Cooper(7), Nels Hamacher(7), Hillard Rubin(7), Kimberly S. Waggie(5), Brandon Harder(5), Thomas R. Bukowski(5), Omar L. Francone(5), Katherine E. Lewis(4), Jahei Ihm(4), Judith A.K. Harmony(4), Jacqueline R. Starr(4), Richard L. Jackson(4), Nancy Avila(4), A.M. Bendele(3), Mark W. Rixon(3), Megan Lantry(3), Mark Maurer(3), Laura J. Smith(3), Deiby Faulkner(3)