Tanja Kortemme

QB3 — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

71h-index27.9kcitations206works24.12yr avg
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Research Topics

Protein Structure and Dynamics(96), RNA and protein synthesis mechanisms(51), Enzyme Structure and Function(49), Computational Drug Discovery Methods(22), Bioinformatics and Genomic Networks(15)

Publications200 total

Machine learning-guided optimization of anti-CD70 natural ligand-based CAR-lymphocytes for Acute Myeloid Leukemia
Blood·2025
All-atom protein design via SE(3) flow matching with ProteinZen
2025Open Access
Structure-guided engineering of CCL27 enhances natural ligand CAR T-cells against CCR10 for multiple myeloma
2025· 1 citedOpen Access
A combinatorial mutational map of active non-native protein kinases by deep learning guided sequence design
2025Open Access
Better together: Elements of successful scientific software development in a distributed collaborative community
UNC Libraries·2025Open Access
An improved model for prediction of de novo designed proteins with diverse geometries
2025Open Access
Deep learning–guided design of dynamic proteins
Science·2025· 34 cited
Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells
Blood·2025· 8 citedOpen Access
Deep learning guided design of dynamic proteins
2024· 8 citedOpen Access
An integrative approach to protein sequence design through multiobjective optimization
PLoS Computational Biology·2024· 14 citedOpen Access
An integrative approach to protein sequence design through multiobjective optimization
2024· 2 citedOpen Access
Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells
2024· 9 citedOpen Access
De novo protein design—From new structures to programmable functions
Cell·2024· 237 citedOpen Access
Structure-conditioned masked language models for protein sequence design generalize beyond the native sequence space
2023· 26 citedOpen Access
Author Correction: Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor
Nature Communications·2023Open Access
Multi-input Drug-Controlled Switches of Mammalian Gene Expression Based on Engineered Nuclear Hormone Receptors
ACS Synthetic Biology·2023· 3 citedOpen Access
Emerging maps of allosteric regulation in cellular networks
Current Opinion in Structural Biology·2023· 16 citedOpen Access
Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor
Nature Communications·2023· 37 citedOpen Access
A complete allosteric map of a GTPase switch in its native cellular network
Cell Systems·2023· 19 citedOpen Access
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Structure·2023· 4 citedOpen Access
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Frequent Co-authors

David Baker(18), Brian Kuhlman(8), Daniel J. Mandell(7), Andrew Leaver‐Fay(6), Rhiju Das(6), Jeffrey J. Gray(6), Colin A. Smith(5), Sergey Lyskov(5), P. Douglas Renfrew(4), James J. Havranek(4), Matthew J. O’Meara(4), Oren S. Rosenberg(4), Michael D. Tyka(3), Steven M. Lewis(3), Ron Jacak(3), Ian Davis(3), David E. Kim(3), John Karanicolas(3), Jens Meiler(3), Philip Bradley(3)