Darren Sigal

Scripps Clinic — United States

Medicine · Health Sciences

23h-index4.0kcitations82works1.32yr avg
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Research Topics

Lung Cancer Treatments and Mutations(15), Pancreatic and Hepatic Oncology Research(14), Chronic Lymphocytic Leukemia Research(13), Lymphoma Diagnosis and Treatment(12), Colorectal Cancer Treatments and Studies(12)

Publications82 total

CD16 and Siglec expression refine the phenotypic heterogeneity of steady-state myeloid-derived suppressor cells
Frontiers in Oncology·2025· 2 citedOpen Access
Detection of Gene Fusions and Rearrangements in Formalin-Fixed, Paraffin-Embedded Solid Tumor Specimens Using High-Throughput Chromosome Conformation Capture
Journal of Molecular Diagnostics·2025· 1 cited
Phase I–II study of OBI-888, a humanized monoclonal IgG1 antibody against the tumor-associated carbohydrate antigen Globo H, in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology·2024· 1 citedOpen Access
Protracted complete response after limited checkpoint inhibitor dosing: A case report
Clinical Case Reports·2023Open Access
3D genomics identifies previously unreported yet clinically actionable gene fusions and complex rearrangements in a cohort of driver-negative colorectal carcinoma tumors.
Journal of Clinical Oncology·2023
<sup>177</sup>Lu-DOTATATE in neuroendocrine tumors: Real-world evidence of efficacy and safety in a community setting.
Journal of Clinical Oncology·2023
Protracted Complete Response After Limited Checkpoint Inhibitor Dosing: A Case Report
2023Open Access
Do patients with metastatic pancreatic adenocarcinoma to the lung have improved survival?
Cancer Medicine·2023· 7 citedOpen Access
A phase I/IIa open label, nonrandomized, multicenter study of CYNK-101 in combination with trastuzumab and pembrolizumab in patients with locally advanced unresectable or metastatic HER2-positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
Journal of Clinical Oncology·2023· 2 cited
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
Cancer Cell·2022· 51 citedOpen Access
Neoadjuvant chemotherapy and radiotherapy outcomes in <scp>borderline‐resectable</scp> and <scp>locally‐advanced</scp> pancreatic cancer patients
Cancer Medicine·2022· 6 citedOpen Access
Abstract 84: Sensitive and unbiased detection of clinically actionable gene fusions from FFPE tumor biopsies using the Arima-HiC platform
Cancer Research·2022
Do patients with metastatic pancreatic adenocarcinoma to the lung have improved survival?
Journal of Clinical Oncology·2022
Abstract P5-08-01: Globo H: A Globo series glycosphingolipid target antigen in breast cancer
Cancer Research·2022· 1 cited
An observational study of hospitalized COVID-19 patients with cancer in San Diego county
Future Oncology·2022· 3 citedOpen Access
Efficacy of SBP-101, a polyamine metabolic inhibitor, administered in combination with gemcitabine and nab-paclitaxel, as a first-line treatment for patients with metastatic pancreatic ductal adenocarcinoma.
Journal of Clinical Oncology·2022· 2 cited
A phase 1 study of ABX196 in combination with nivolumab in patients with previously treated hepatocellular carcinoma (HCC).
Journal of Clinical Oncology·2022· 4 cited
The role of Globo H and SSEA-4 in the Development and Progression of Cancer, and their Potential as Therapeutic Targets
Future Oncology·2021· 31 citedOpen Access
SBP-101, a polyamine metabolic inhibitor, administered in combination with gemcitabine and nab-paclitaxel, shows signals of efficacy as first-line treatment for subjects with metastatic pancreatic ductal adenocarcinoma.
Journal of Clinical Oncology·2021· 7 cited
Association of systemic anticancer therapy with an increased risk of death in hospitalized COVID-19 positive oncology patients.
Journal of Clinical Oncology·2021
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Frequent Co-authors

Nathan Bahary(11), Alan Saven(10), Andrew Hendifar(8), Robert C. Doebele(7), Sunil R. Hingorani(7), Andrea J. Bullock(7), Brian Simmons(6), Tara Elisabeth Seery(6), William Proctor Harris(6), Mitesh J. Borad(6), George D. Demetri(6), Luis Paz‐Ares(5), Anna F. Farago(5), Takashi Seto(5), Diégo Tosi(5), Benjamin Besse(5), John C. Krauss(5), Stephen V. Liu(5), Edna Chow‐Maneval(5), Lei Zheng(5)