Ernst‐Jan M. Speel

Maastricht University Medical Centre — Netherlands

Medicine · Health Sciences

60h-index12.4kcitations354works2.02yr avg
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Research Topics

Neuroendocrine Tumor Research Advances(99), Lung Cancer Research Studies(92), Neuroblastoma Research and Treatments(64), Head and Neck Cancer Studies(63), Lung Cancer Treatments and Mutations(44)

Publications351 total

Treatment outcomes in patients with stage IV large cell neuroendocrine carcinoma: a nationwide registry study
Lung Cancer·2025Open Access
Actionable Genomic Alterations in Large Cell Neuroendocrine Carcinoma: A European Case Series of Patients Treated With a Small Molecule Inhibitor
JCO Precision Oncology·2025· 1 cited
Determining the optimal approach to identify osimertinib resistance; the first line osimertinib cohort of the OSIRIS study
Lung Cancer·2025Open Access
Analytical Validation of a Pan-Cancer Next-Generation Sequencing Assay for In-House Liquid Biopsy Testing
Journal of Molecular Diagnostics·2025Open Access
Comprehensive Analysis of Neurogenic Differentiation Factor 1 (NEUROD1), Achaete-Scute Homolog 1 (ASCL1), POU Class 2 Homeobox 3 (POU2F3), and Yes-Associated Protein 1 (YAP1) Expression Signatures Reveals Unique Large-Cell Neuroendocrine Carcinoma (LCNEC) Subgroups With Potential Therapeutic Implications
Laboratory Investigation·2025· 1 citedOpen Access
Clinical insight on the pathway of SLFN11 as emergent biomarker in SCLC
Critical Reviews in Oncology/Hematology·2025· 1 citedOpen Access
Controversies in <scp>NEN</scp> : An <scp>ENETS</scp> position statement on the treatment of patients with Grade 3 well‐differentiated neuroendocrine tumours of the gastro‐enteropancreatic tract
Journal of Neuroendocrinology·2025· 2 citedOpen Access
A clinically relevant morpho-molecular classification of lung neuroendocrine tumours
2025· 1 citedOpen Access
Deep Learning–Based Retinoblastoma Protein Subtyping of Pulmonary Large-Cell Neuroendocrine Carcinoma on Small Hematoxylin and Eosin–Stained Specimens
Laboratory Investigation·2025· 2 citedOpen Access
Abstract 6362: Characterization of therapeutic effects in glioblastoma through integrated spatial single-cell multiome profiling of longitudinal samples: Unveiling clinically relevant subtypes of pathological changes
Cancer Research·2025
A Response to the Letter to the Editor: “Linear Versus Non-Linear: Debunking Critiques on PCA Use in Molecular Subgrouping of Pulmonary Carcinoids”
Journal of Thoracic Oncology·2025· 1 cited
The significance of <scp>PAX5</scp> in Merkel cell carcinoma
The Journal of Pathology·2025· 3 citedOpen Access
Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics
Molecular Oncology·2025· 1 citedOpen Access
Exploring the antiproliferative effect of PI3K/Akt/mTOR pathway and CDK4/6 inhibitors in human papillomavirus‑positive and ‑negative head and neck squamous cell carcinoma cell lines
International Journal of Oncology·2025· 6 citedOpen Access
OTP, CD44, and Ki-67: A Prognostic Marker Panel for Relapse-Free Survival in Patients with Surgically Resected Pulmonary Carcinoid
Modern Pathology·2024· 4 citedOpen Access
Author response for "Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics"
2024
TMIC-55. CHARACTERIZATION OF THERAPEUTICS EFFECTS IN GLIOBLASTOMA THROUGH INTEGRATED SPATIAL SINGLE-CELL MULTIOME PROFILING OF LONGITUDINAL SAMPLES: UNVEILING CLINICALLY RELEVANT SUBTYPES OF PATHOLOGICAL CHANGES
Neuro-Oncology·2024· 1 citedOpen Access
Analytical Validation of a Pan-Cancer NGS Assay for In-House Liquid Biopsy Testing: An International Multicenter Study
2024· 2 citedOpen Access
<i>TERT</i> Expression and Clinical Outcome in Pulmonary Carcinoids
Journal of Clinical Oncology·2024· 10 citedOpen Access
Proximity ligation‐based sequencing for the identification of human papillomavirus genomic integration sites in formalin‐fixed paraffin embedded oropharyngeal squamous cell carcinomas
Journal of Medical Virology·2024· 1 citedOpen Access
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Frequent Co-authors

Paul Komminoth(13), Erik Thunnissen(10), Parvin Saremaslani(10), Philipp U. Heitz(10), Frans C. S. Ramaekers(9), Anne‐Marie C. Dingemans(9), Bernd Kremer(8), Anton H. N. Hopman(8), Annick Haesevoets(7), Jens Peter Klußmann(7), Jürgen Roth(7), Jianming Zhao(6), Aurel Perren(5), Harriët C. Hafkamp(5), Johannes J. Manni(5), Seraina Muletta-Feurer(5), Jules L. Derks(4), Harry J.M. Groen(4), Egbert F. Smit(4), Katrin Rütimann(4)