Miljan Simonović

University of Illinois Chicago — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.3kcitations73works2.32yr avg
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Research Topics

RNA and protein synthesis mechanisms(27), RNA modifications and cancer(24), Selenium in Biological Systems(14), Enzyme Structure and Function(12), Trace Elements in Health(9)

Publications73 total

Structural basis of Cas9 DNA interrogation with a 5′ truncated sgRNA
Nucleic Acids Research·2024· 5 citedOpen Access
Human selenocysteine synthase, SEPSECS, has evolved to optimize binding of a tRNA-based substrate
Nucleic Acids Research·2024Open Access
De novo missense variants in exon 9 of SEPHS1 cause a neurodevelopmental condition with developmental delay, poor growth, hypotonia, and dysmorphic features
The American Journal of Human Genetics·2024Open Access
De novo missense variants in exon 9 of SEPHS1 cause a neurodevelopmental condition with developmental delay, poor growth, hypotonia, and dysmorphic features
The American Journal of Human Genetics·2024· 4 citedOpen Access
Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans
Nucleic Acids Research·2023· 4 citedOpen Access
Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon
Science·2022· 59 citedOpen Access
Structural studies of human selenoprotein synthesis
Acta Crystallographica Section A Foundations and Advances·2019Open Access
Harnessing SAXS and X-ray crystallography for high-resolution structural studies of macromolecules
Acta Crystallographica Section A Foundations and Advances·2019Open Access
Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9
Nature Structural & Molecular Biology·2019· 169 cited
Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium
2019
Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium
2019· 92 cited
On elongation factor eEFSec, its role and mechanism during selenium incorporation into nascent selenoproteins
Biochimica et Biophysica Acta (BBA) - General Subjects·2018· 20 citedOpen Access
Insights into substrate promiscuity of human seryl-tRNA synthetase
RNA·2017· 26 citedOpen Access
Human aminoacyl-tRNA synthetases in diseases of the nervous system
RNA Biology·2017· 94 citedOpen Access
Regulation of the Stoichiometry of the Human Selenocysteine Synthase (SepSecS) Catalytic Complex
The FASEB Journal·2017
Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation
Nature Communications·2016· 35 citedOpen Access
Selenoprotein Gene Nomenclature
Journal of Biological Chemistry·2016· 265 citedOpen Access
Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase
Scientific Reports·2016· 14 citedOpen Access
Crystal structure and biophysical characterization of ligand-free and -bound RNases 4 and 6, members of the human RNase A superfamily
Acta Crystallographica Section A Foundations and Advances·2016Open Access
The crystal structure of human eEFSec in complex with GDP
2016
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Frequent Co-authors

Karl Volz(10), Dieter Söll(8), Peter G.W. Gettins(8), Anupama K. Puppala(7), Thomas A. Steitz(6), Ivana Simonović(5), Rachel L. French(5), Jiqiang Ling(5), Paul R. Copeland(4), Bradley J. Merrill(4), Sriram Subramaniam(4), Kaitlyn Kiernan(4), Ryan Clarke(3), Sagar Chittori(3), Alan Merk(3), Sotiria Palioura(3), Jana Ognjenović(3), Jon S. Morrow(3), Malgorzata Dobosz-Bartoszek(3), Kaitlyn M. Holman(3)