Ruth E. Silversmith

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index1.4kcitations69works0.02yr avg
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Research Topics

Bacterial Genetics and Biotechnology(22), Protein Structure and Dynamics(21), RNA and protein synthesis mechanisms(13), Enzyme Structure and Function(9), Lipid Membrane Structure and Behavior(7)

Publications69 total

Alteration of a Nonconserved Active Site Residue in the Chemotaxis Response Regulator CheY Affects Phosphorylation and Interaction with CheZ
UNC Libraries·2021Open Access
Kinetic Characterization of Catalysis by the Chemotaxis Phosphatase CheZ: MODULATION OF ACTIVITY BY THE PHOSPHORYLATED CheY SUBSTRATE
UNC Libraries·2021· 3 citedOpen Access
Role of Position K+4 in the Phosphorylation and Dephosphorylation Reaction Kinetics of the CheY Response Regulator
Biochemistry·2021· 8 citedOpen Access
A Link between Dimerization and Autophosphorylation of the Response Regulator PhoB
UNC Libraries·2020Open Access
Conformational coupling in the chemotaxis response regulator CheY
UNC Libraries·2020· 2 citedOpen Access
Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate
UNC Libraries·2020· 1 citedOpen Access
Investigation of the Role of Electrostatic Charge in Activation of the Escherichia coli Response Regulator CheY
UNC Libraries·2020Open Access
Isolation and Characterization of Nonchemotactic CheZ Mutants of Escherichia coli
UNC Libraries·2020· 1 citedOpen Access
Action at a Distance: Amino Acid Substitutions That Affect Binding of the Phosphorylated CheY Response Regulator and Catalysis of Dephosphorylation Can Be Far from the CheZ Phosphatase Active Site
UNC Libraries·2020· 2 citedOpen Access
Matching Biochemical Reaction Kinetics to the Timescales of Life: Structural Determinants That Influence the Autodephosphorylation Rate of Response Regulator Proteins
UNC Libraries·2020Open Access
CheZ-Mediated Dephosphorylation of the Escherichia coli Chemotaxis Response Regulator CheY: Role for CheY Glutamate 89
UNC Libraries·2020Open Access
CheX Is a Phosphorylated CheY Phosphatase Essential for Borrelia burgdorferi Chemotaxis
UNC Libraries·2020· 3 citedOpen Access
Auxiliary phosphatases in two-component signal transduction
UNC Libraries·2020Open Access
Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases
Figshare·2020Open Access
Imidazole as a Small Molecule Analogue in Two-Component Signal Transduction
UNC Libraries·2020Open Access
Nonconserved Active Site Residues Modulate CheY Autophosphorylation Kinetics and Phosphodonor Preference
UNC Libraries·2020Open Access
Phosphoryl Group Flow within the Pseudomonas aeruginosa Pil-Chp Chemosensory System: DIFFERENTIAL FUNCTION OF THE EIGHT PHOSPHOTRANSFERASE AND THREE RECEIVER DOMAINS
UNC Libraries·2020· 1 citedOpen Access
A Variable Active Site Residue Influences the Kinetics of Response Regulator Phosphorylation and Dephosphorylation
Figshare·2020Open Access
Measuring the Activities of Two-Component Regulatory System Phosphatases
Methods in enzymology on CD-ROM/Methods in enzymology·2018· 3 cited
Fluorescence Measurement of Kinetics of CheY Autophosphorylation with Small Molecule Phosphodonors
Methods in molecular biology·2018· 4 cited
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Frequent Co-authors

Robert B. Bourret(33), Edward J. Collins(5), Robert M. Immormino(5), Martín Schuster(4), Md A. Motaleb(4), Gerald P. Guanga(4), Gary L. Nelsestuen(4), Jenny G. Smith(3), Y. Pazy(3), Stéphanie Thomas(3), Walid N. Abouhamad(3), Stuart F. Goldstein(2), Nyles W. Charon(2), Jamie A. Latiolais(2), Michael T. Guarnieri(2), Rui Zhao(2), Kristin C. Boesch(2), Rachel L. Creager-Allen(2), Matthew D. Levin(2), Elmar Schilling(2)