Siyuan Le

Regend Therapeutics (China) — China

Medicine · Health Sciences

8h-index3.7kcitations17works1.82yr avg
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Research Topics

Cancer-related Molecular Pathways(4), Telomeres, Telomerase, and Senescence(4), RNA Interference and Gene Delivery(3), Genomics and Chromatin Dynamics(2), Cell death mechanisms and regulation(2)

Publications17 total

Discovery of Fulzerasib (GFH925) for the Treatment of KRAS G12C-Mutated Solid Tumors
Journal of Medicinal Chemistry·2025· 2 cited
Abstract 389: GFH276: A molecular glue panRAS(on) inhibitor with broad spectrum anti-tumor activities
Cancer Research·2025
Abstract 6078: GFS202A, a novel GDF15×IL-6 bispecific antibody for the treatment of cachexia
Cancer Research·2025
Abstract 4394: GFH375 (VS-7375): An oral, selective KRAS G12D (ON/OFF) inhibitor with potent anti-tumor efficacy as single agent and in combination with other anticancer therapies in preclinical models
Cancer Research·2025· 3 cited
Abstract LB165: GFH547: An orally bioavailable, cyclophilin A-hijacking panRAS(on) inhibitor with broad spectrum anti-tumor activities
Cancer Research·2024
Abstract 3318: GFH375 (VS-7375): An oral, selective KRAS G12D (ON/OFF) inhibitor with potent anti-tumor efficacy
Cancer Research·2024· 6 cited
The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies
Oncotarget·2023· 3 citedOpen Access
In Vitro and In Vivo Studies Support GFH009, a Selective CDK9 Inhibitor, As a Potential Treatment for Hematologic Cancers
Blood·2022· 3 cited
Comparing Protein and mRNA Abundances to Protein Expression Regulation
Europe PMC (PubMed Central)·2011
JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis
Neuron·2003· 508 citedOpen Access
c-Jun N-terminal Kinase Specifically Phosphorylates p66ShcA at Serine 36 in Response to Ultraviolet Irradiation
Journal of Biological Chemistry·2001· 97 citedOpen Access
Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA
Molecular Biology of the Cell·2000· 132 cited
RAD50 and RAD51 Define Two Pathways That Collaborate to Maintain Telomeres in the Absence of Telomerase
Genetics·1999· 401 citedOpen Access
Telomerase Activity in Human Gliomas
Neurosurgery·1998· 67 cited
Two New S-Phase-Specific Genes fromSaccharomyces cerevisiae
Yeast·1997· 213 cited
The RNA Component of Human Telomerase
Science·1995· 2.2k cited
Nucleosome fractionation by mercury affinity chromatography. Contrasting distribution of transcriptionally active DNA sequences and acetylated histones in nucleosome fractions of wild-type yeast cells and cells expressing a histone H3 gene altered to encode a cysteine 110 residue.
Journal of Biological Chemistry·1991· 57 citedOpen Access

Frequent Co-authors

Jiong Lan(8), Carol W. Greider(4), Fubo Xie(4), Rolf Sternglanz(3), Leitao Zhang(3), Hongcan Ren(3), Lili Tang(3), Fusheng Zhou(3), Qiang Lü(3), Fusheng Zhou(3), Mei Ge(3), Jinmin Ren(3), Anna C. Maroney(2), Feng Yan(2), Tao Jiang(2), Liang Tao(2), Lijian Cai(2), Yan Zha(2), Xiaoling Lan(2), Jinting Gao(2)