Yuet Wai Kan

Tongji University — China

Medicine · Health Sciences

82h-index23.7kcitations242works5.22yr avg
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Research Topics

Hemoglobinopathies and Related Disorders(104), CRISPR and Genetic Engineering(43), Iron Metabolism and Disorders(38), Prenatal Screening and Diagnostics(34), Virus-based gene therapy research(25)

Publications242 total

ROS-related nanoparticles for the management of Alzheimer’s disease: Wielding the double-edged sword
Chemical Engineering Journal·2025· 6 cited
Photodynamic therapy Mediated by inflammatory responsive hydrogel for the treatment of infectious arthritis
Journal of Drug Delivery Science and Technology·2025
Cuproptosis and copper as potential mechanisms and intervention targets in Alzheimer's disease
Biomedicine & Pharmacotherapy·2025· 14 citedOpen Access
Baihui‐Penetrating‐Qubin Acupuncture Attenuates Neurological Deficits Through SIRT1/FOXO1 Reducing Oxidative Stress and Neuronal Apoptosis in Intracerebral Hemorrhage Rats
Brain and Behavior·2024· 6 citedOpen Access
Author response for "Baihui‐Penetrating‐Qubin Acupuncture Attenuates Neurological Deficits Through SIRT1/FOXO1 Reducing Oxidative Stress and Neuronal Apoptosis in Intracerebral Hemorrhage Rats"
2024
Seamless Gene Correction in the Human Cystic Fibrosis Transmembrane Conductance Regulator Locus by Vector Replacement and Vector Insertion Events
Frontiers in Genome Editing·2022· 2 citedOpen Access
Genetically edited CD34 <sup>+</sup> cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells
Proceedings of the National Academy of Sciences·2021· 6 citedOpen Access
Induction of therapeutic levels of HbF in genome‐edited primary β<sup>0</sup>39‐thalassaemia haematopoietic stem and progenitor cells
British Journal of Haematology·2020· 15 citedOpen Access
Genetically-edited induced pluripotent stem cells derived from HIV-1-infected patients on therapy can give rise to immune cells resistant to HIV-1 infection
AIDS·2020· 22 cited
CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1<sup>T315I</sup> mutation mouse model
Haematologica·2019· 6 citedOpen Access
Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor
Proceedings of the National Academy of Sciences·2018· 65 citedOpen Access
Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia
Proceedings of the National Academy of Sciences·2016· 186 citedOpen Access
Reversible Immortalization Enables Seamless Transdifferentiation of Primary Fibroblasts into Other Lineage Cells
Stem Cells and Development·2016· 7 citedOpen Access
A 36-base-pair core sequence of locus control region enhances retrovirally transferred human fl-globin gene expression (hypersensitive sites/NFE-2/AP-1/N2A vector/+,-2 and PA317 packaging cell lines)
2016
Triplicated a-globin loci in humans (restriction endonuclease mapping/unequal crossing-over/ai thalassemia/polymorphism)
2016
TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs
Molecular Therapy — Nucleic Acids·2016· 41 citedOpen Access
Nrf2 in health and disease: current and future clinical implications
Clinical Science·2015· 122 cited
Nrf2 augments skeletal muscle regeneration after ischaemia–reperfusion injury
The Journal of Pathology·2014· 57 cited
Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and <i>piggyBac</i>
Genome Research·2014· 403 citedOpen Access
Nrf2 Deficiency Impairs Fracture Healing in Mice
Calcified Tissue International·2014· 49 cited
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Frequent Co-authors

Andrée M. Dozy(7), Kaimin Chan(6), Judy C. Chang(6), Antonio Cao(5), D. Todd(4), Jeffrey A. Johnson(3), Ashley I. Beyer(3), Marcus O. Muench(3), Stephen H. Embury(3), A M Dozy(3), Stephen A. Liebhaber(3), Éric Clauser(2), William J. Rutter(2), Marcus J. Calkins(2), Ronghua Lu(2), Delinda A. Johnson(2), Ulrich auf dem Keller(2), Sabine Werner(2), Lin Ye(2), Jiaming Wang(2)