Ryan J. H. West

University of Sheffield — United Kingdom

Medicine · Health Sciences

13h-index532citations33works1.02yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(11), Retinal Development and Disorders(8), Neurobiology and Insect Physiology Research(7), Cellular transport and secretion(6), Alzheimer's disease research and treatments(5)

Publications33 total

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA
International Journal of Molecular Sciences·2026Open Access
M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis
Molecular Neurodegeneration·2025Open Access
Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis
Brain·2025· 3 citedOpen Access
The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
2025· 1 citedOpen Access
RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD
Life Science Alliance·2024· 1 citedOpen Access
The role of Ataxin‐2 in Drosophila models of C9orf72‐related FTD expressing dipeptide‐repeats of a physiologically relevant length
Alzheimer s & Dementia·2023Open Access
Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity
Acta Neuropathologica Communications·2023· 7 citedOpen Access
Identification and Monitoring of Nucleotide Repeat Expansions Using Southern Blotting in Drosophila Models of C9orf72 Motor Neuron Disease and Frontotemporal Dementia
BIO-PROTOCOL·2022· 1 citedOpen Access
Modeling C9orf72-Related Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Drosophila
Frontiers in Cellular Neuroscience·2021· 10 citedOpen Access
Lessons learned from CHMP2B, implications for frontotemporal dementia and amyotrophic lateral sclerosis
Neurobiology of Disease·2020· 44 citedOpen Access
Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila
Acta Neuropathologica Communications·2020· 36 citedOpen Access
Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila
Scientific Reports·2020· 11 citedOpen Access
Neuroprotective activity of ursodeoxycholic acid in CHMP2B models of frontotemporal dementia
Neurobiology of Disease·2020· 22 citedOpen Access
Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila
White Rose Research Online (University of Leeds, The University of Sheffield, University of York)·2020Open Access
Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila
eLife·2018· 116 citedOpen Access
Autism sensory dysfunction in an evolutionarily conserved system
Proceedings of the Royal Society B Biological Sciences·2018· 17 citedOpen Access
Author response: Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila
2018· 1 citedOpen Access
Sphingolipids regulate neuromuscular synapse structure and function in <i>Drosophila</i>
The Journal of Comparative Neurology·2018· 22 citedOpen Access
Autism sensory dysfunction in an evolutionarily conserved system
2018· 3 citedOpen Access
The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia
Human Molecular Genetics·2018· 17 citedOpen Access
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Frequent Co-authors

Sean T. Sweeney(9), Christopher Elliott(8), Alex R. Wade(5), Richard A. Baines(4), Joanne L. Sharpe(4), Greta Vilidaitė(4), Anthony M. Norcia(4), Francesca Pei(4), Daniel H. Baker(4), Matthew C. W. Oswald(3), Fen‐Biao Gao(3), Chris Ugbode(3), Nikki S. Harper(3), Pamela J. Shaw(3), Paul Brooks(2), Maarten Zwart(2), Amrita Mukherjee(2), Carlo NG Giachello(2), Khomgrit Morarach(2), Matthias Landgraf(2)