Frank W.G. Leebeek

Erasmus MC — Netherlands

Medicine · Health Sciences

71h-index20.1kcitations599works3.82yr avg
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Research Topics

Platelet Disorders and Treatments(228), Hemophilia Treatment and Research(164), Blood Coagulation and Thrombosis Mechanisms(107), Venous Thromboembolism Diagnosis and Management(89), Blood groups and transfusion(74)

Publications595 total

Allele-selective disruption of pathogenic <i>VWF</i> variants in type 2 von Willebrand disease using CRISPR/Cas9
Blood Advances·2025Open Access
Final Analysis of a Study of Etranacogene Dezaparvovec for Hemophilia B
New England Journal of Medicine·2025· 2 cited
Pharmacokinetic-guided dose reduction of emicizumab in congenital hemophilia A: interim analysis of the DosEmi study
Journal of Thrombosis and Haemostasis·2025· 1 citedOpen Access
Correction: Rewriting the script: gene therapy and genome editing for von Willebrand Disease
Frontiers in Genome Editing·2025Open Access
Recombinant von willebrand factor for perioperative management of bleeding in pediatric patients with severe von willebrand disease: Interim results from a phase 3 multicenter study and a phase 3b continuation study
Blood·2025Open Access
High risk of bleeding following CAR T-cell therapy: Insights from the dutch “Follow that CAR!” registry
Blood·2025Open Access
End-of-study analysis of the HOPE-B trial confirms the durable efficacy and safety of etranacogene dezaparvovec hemophilia b gene therapy over 5 years
Blood·2025
Heterozygous nonsense FLI1 p.Met100∗ variant results in thrombocytopenia and increased erythroid gene expression
Research and Practice in Thrombosis and Haemostasis·2025Open Access
A comprehensive care pathway of gene therapy for hemophilia based on current guideline documents and summary of product characteristics: communication from the ISTH SSC working group on gene therapy
Journal of Thrombosis and Haemostasis·2025Open Access
Sex differences in outcomes of vitamin K antagonist treatment in patients with a mechanical heart valve: a Dutch population-based cohort study
Journal of Thrombosis and Haemostasis·2025· 1 citedOpen Access
Large deletions in the F8 gene predict immune tolerance induction failure in people with severe hemophilia A
Research and Practice in Thrombosis and Haemostasis·2025Open Access
Rewriting the script: gene therapy and genome editing for von Willebrand Disease
Frontiers in Genome Editing·2025· 2 citedOpen Access
von Willebrand disease-specific defects and proteomic signatures in endothelial colony–forming cells
Journal of Thrombosis and Haemostasis·2025· 3 citedOpen Access
Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF
Blood·2025· 4 citedOpen Access
Completion of phase 2b trial of etranacogene dezaparvovec gene therapy in patients with hemophilia B over 5 years
Blood Advances·2025· 12 citedOpen Access
Mild or moderate hemophilia is not always a mild or moderate bleeding disorder: Back to the clinical phenotype
HemaSphere·2025· 2 citedOpen Access
Sexuality and bleeding in von Willebrand disease
Research and Practice in Thrombosis and Haemostasis·2025· 2 citedOpen Access
Stable Factor IX Expression and Sustained Reductions in Factor IX Use 8 Years After Gene Therapy With CSL220 (Formerly AMT-060) in Adults with Hemophilia B [ENCORE]
Hämostaseologie·2025· 1 cited
Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs
Blood Advances·2025· 8 citedOpen Access
Replacement therapy in pregnant women with von Willebrand disease during delivery: Factor levels and pharmacokinetics
HemaSphere·2025· 2 citedOpen Access
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Frequent Co-authors

Moniek P.M. de Maat(13), Karina Meijer(7), Harry L.A. Janssen(6), Jeroen Eikenboom(5), Dominique Valla(5), Juan Carlos García‐Pagán(5), Giancarlo Castaman(5), Karin Fijnvandraat(5), Ton Lisman(4), Albert Hofman(4), Aurélie Plessier(4), Sarwa Darwish Murad(4), Wolfgang Miesbach(4), Britta A. P. Laros‐van Gorkom(4), Johanna G. van der Bom(4), Marieke J.H.A. Kruip(4), T.N. Bongers(3), Philip G. de Groot(3), Peter A. Kouides(3), Nigel S. Key(3)