Mohamed A. Helal

Suez Canal University — Egypt

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index894citations60works3.12yr avg
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Research Topics

Receptor Mechanisms and Signaling(12), Computational Drug Discovery Methods(9), Synthesis and biological activity(5), Signaling Pathways in Disease(5), Bioactive Compounds and Antitumor Agents(4)

Publications60 total

Synthesis, Characterization, and Biological Evaluation of Novel Isatin‐Bearing Amino Acid Derivatives: Cytotoxic Activity and Prospective Applications in Medicinal Chemistry
ChemistrySelect·2026
Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus
Scientific Reports·2025Open Access
The metal ions (Cu(II), Co(II), Ni(II), Mn(II), and UO2(II)) effect on structural, protein binding, in vitro antimicrobial and anticancer potential of quinoline-aminobenzoic acid mixed ligand complexes
Journal of Molecular Structure·2025· 2 cited
Discovery of indole- and quinolone-based inhibitors of the mTOR/Akt/Pi3K pathway for the potential treatment of autism and certain types of cancer
RSC Medicinal Chemistry·2025Open Access
Author response for "Discovery of indole- and quinolone-based inhibitors of the mTOR/Akt/Pi3K pathway for the potential treatment of autism and certain types of cancer"
2025
Betanin mitigates vancomycin-induced acute kidney injury in mice and molecular docking indicated inhibition of STAT3 phosphorylation
Tissue and Cell·2025
Design and synthesis of novel small molecules targeting the Kv1.3 voltage-gated potassium ion channel
Scientific Reports·2025· 1 citedOpen Access
Recent Advances in the Development of Pro-PROTAC for Selective Protein Degradation
Pharmaceutics·2025· 2 citedOpen Access
Development, biological evaluation, and molecular modelling of novel isocytosine and guanidine derivatives as BACE1 inhibitors using a fragment growing strategy
RSC Medicinal Chemistry·2025· 1 citedOpen Access
Molecular Docking, Bioinformatic Analysis, and Experimental Verification for the Effect of Naringin on ADHD: Possible Inhibition of GSK-3β and HSP90
Pharmaceuticals·2024· 6 citedOpen Access
Atropisomerism in Drug Discovery and Development
2024
The Creation and Validation of a New High-Performance Liquid Chromatography Method for Analyzing Pyridostigmine Bromide and its Degradation Products in a Pharmaceutical Formulation
SINAI International Scientific Journal.·2024Open Access
Effectiveness of autologous leucocyte and platelet-rich fibrin (L-PRF) in management of chronic diabetic foot ulcers.
The Egyptian Journal of Surgery·2024Open Access
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147
Cell Communication and Signaling·2024· 31 citedOpen Access
Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey
BMC Psychology·2024· 6 citedOpen Access
Development, Biological Evaluation, and Molecular Modelling of Novel Isocytosine and Guanidine Derivatives as Bace1 Inhibitors Using a Fragment Growing Strategy
SSRN Electronic Journal·2024Open Access
Novel fluorescence approach for trace quantification of levonorgestrel in breast milk based on click reaction with benzonitrofurazan azide (NBD-AZ)
Methods and Applications in Fluorescence·2023Open Access
4‐Azido‐7‐nitrobenzoxadiazole as innovative clickable fluorescence probe for trace and selective quantification of ethinylestradiol in human plasma
Luminescence·2023· 2 cited
Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF-κB pathway: Molecular docking and biological investigations
Biomedicine & Pharmacotherapy·2023· 30 citedOpen Access
Structure-based design of novel melanin-concentrating hormone receptor-1 ligands based on saturated nitrogen-containing heterocycles
Bioorganic & Medicinal Chemistry Letters·2023· 1 cited
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Frequent Co-authors

Ahmad Abdelwaly(12), Ismail Salama(9), Khaled M. Darwish(8), Mohamed S. Gomaa(6), Amar G. Chittiboyina(6), Samia M. Mostafa(5), Mohamed Saleh Elgawish(5), Safaa M. Kishk(4), Sawsan A. Zaitone(4), Shaimaa Shouman(3), Ahmed O. Elmehrath(3), Amr Hany Saleh(3), Nagwa El‐Badri(3), Sebastiano Intagliata(3), Eman S. Habib(3), Claire Simons(3), Safwat A. Ahmed(3), Mitchell A. Avery(3), Asmaa M. Atta(3), Samia M. Moustafa(3)