Danielle Pinner

Great Ormond Street Hospital — United Kingdom

Medicine · Health Sciences

9h-index2.6kcitations14works2.02yr avg
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Research Topics

CAR-T cell therapy research(12), Virus-based gene therapy research(4), CRISPR and Genetic Engineering(4), Hematopoietic Stem Cell Transplantation(2), Acute Lymphoblastic Leukemia research(2)

Publications13 total

Long term outcomes of genome edited 'universal' CAR19 T-cells for relapsed/refractory B-ALL at a single pediatric centre
Blood Advances·2025· 2 citedOpen Access
CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL
Blood·2023· 62 citedOpen Access
Dual Antigen Targeting with Co-Transduced CD19/22 CAR T Cells May Prevent Antigen-Negative Relapse after CAR T Cell Therapy for Relapsed/Refractory ALL
Blood·2022· 4 cited
Tvt CAR7: Phase 1 Clinical Trial of Base-Edited "Universal” CAR7 T Cells for Paediatric Relapsed/Refractory T-ALL
Blood·2022· 11 cited
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia
Science Translational Medicine·2022· 160 cited
TT52CAR19: Phase 1 Trial of CRISPR/Cas9 Edited Allogeneic CAR19 T Cells for Paediatric Relapsed/Refractory B-ALL
Blood·2021· 5 cited
Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies
The Lancet·2020· 345 citedOpen Access
Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile
Blood·2019· 4 cited
Proposed Therapeutic Range of Treosulfan in Reduced Toxicity Pediatric Allogeneic Hematopoietic Stem Cell Transplant Conditioning: Results From a Prospective Trial
Clinical Pharmacology & Therapeutics·2019· 31 citedOpen Access
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR
Nature Medicine·2019· 613 citedOpen Access
A Novel Low Affinity CD19CAR Results in Durable Disease Remissions and Prolonged CAR T Cell Persistence without Severe CRS or Neurotoxicity in Patients with Paediatric ALL
Blood·2017· 8 cited
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
Science Translational Medicine·2017· 872 cited
First Clinical Application of Talen Engineered Universal CAR19 T Cells in B-ALL
Blood·2015· 94 cited

Frequent Co-authors

Paul Veys(12), Kimberly Gilmour(11), Giovanna Lucchini(11), Robert Chiesa(11), Ajay Vora(11), Kanchan Rao(11), Jan Chu(10), Stuart Adams(9), Sarah Inglott(9), Waseem Qasim(8), Sara Ghorashian(8), Sujith Samarasinghe(7), Persis Amrolia(7), Martin Pulé(7), Farzin Farzaneh(6), Juliana Silva(6), Arina Lazareva(6), Hong Zhan(5), Gary Wright(5), Jack Bartram(5)