Oscar Hernandez‐Alba

Centre National de la Recherche Scientifique — France

Medicine · Health Sciences

16h-index1.0kcitations58works3.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(29), Protein purification and stability(19), Mass Spectrometry Techniques and Applications(18), Analytical Chemistry and Chromatography(12), HER2/EGFR in Cancer Research(9)

Publications58 total

Toward site-specific characterization of structural perturbations on glycosylated Fc using NMR at natural abundance
Journal of Biomolecular NMR·2026Open Access
New Frontiers in ADC Analysis: Advances in Chromatography, Electrophoresis, and Mass Spectrometry
The AAPS Journal·2025· 2 cited
Toward Site-Specific Characterization of Structural Perturbations on Glycosylated Fc Using NMR at Natural Abundance
2025Open Access
Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G-Quadruplexes and Their Protein Binding Partners
ACS Bio & Med Chem Au·2025· 2 citedOpen Access
BPS2025 - Unravelling successive steps in Fe-S cluster biosynthesis by the mitochondrial ISC machinery focusing on the ISCU scaffold protein
Biophysical Journal·2025
Development of Top-Down Mass Spectrometry Strategies in the Chromatographic Time Scale (LC-TD-MS) for the Extended Characterization of an Anti-EGFR Single-Domain Antibody-Drug Conjugate in Both Reduced and Nonreduced Forms
Analytical Chemistry·2025· 1 citedOpen Access
The ISC machinery assembles [2Fe–2S] clusters by formation and fusion of [1Fe–1S] precursors
Nature Chemical Biology·2025· 8 citedOpen Access
Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents
Journal of Medicinal Chemistry·2024· 5 citedOpen Access
Therapeutic Monoclonal Antibody─Antidrug Antibody Affinity Constant Determination Using Capillary Electrophoresis–Tandem Mass Spectrometry
Analytical Chemistry·2024· 4 citedOpen Access
Modular Semisynthetic Approach to Generate T Cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies
Bioconjugate Chemistry·2024· 1 citedOpen Access
A Modular Semi-Synthetic Approach to Generate T cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies
2024Open Access
Development of fine-tuned top-down mass spectrometry strategies in the chromatographic time scale (LC-TD-MS) for the complete characterization of an anti EGFR single domain antibody-drug conjugate (sdADC)
2024· 1 citedOpen Access
Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction
ChemBioChem·2024· 5 citedOpen Access
Denaturing mass photometry for rapid optimization of chemical protein-protein cross-linking reactions
Nature Communications·2024· 11 citedOpen Access
SEC-MS in denaturing conditions (dSEC-MS) for in-depth analysis of rebridged monoclonal antibody-based formats
Talanta·2024· 5 citedOpen Access
Site‐Selective Protein Conjugation by a Multicomponent Ugi Reaction
Chemistry - A European Journal·2023· 12 citedOpen Access
Improved characterization of trastuzumab deruxtecan with PTCR and internal fragments implemented in middle-down MS workflows
Analytical and Bioanalytical Chemistry·2023· 12 citedOpen Access
Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry
Bioconjugate Chemistry·2023· 7 citedOpen Access
CCDC 2269564: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
Cysteine‐Cysteine Cross‐Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine‐Electrophilic Reagent
Chemistry - A European Journal·2023· 11 citedOpen Access
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Frequent Co-authors

Sarah Cianférani(47), Alain Beck(18), Anthony Ehkirch(13), Rania Benazza(12), Evolène Deslignière(11), Davy Guillarme(10), Valentina D’Atri(9), Olivier Colas(8), Stéphane Erb(8), Hélène Diemer(7), Guilhem Chaubet(7), Thomas Botzanowski(6), Ilias Koutsopetras(5), Florent Rouvière(4), Alexandre Goyon(4), Sabine Heinisch(4), Elsa Wagner‐Rousset(4), Alexandre Detappe(4), Valentine Vaur(4), Léa N. C. Rochet(4)