Shamsudheen Karuthedath Vellarikkal

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index2.6kcitations100works9.02yr avg
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Research Topics

Cancer-related molecular mechanisms research(16), RNA modifications and cancer(15), RNA and protein synthesis mechanisms(11), Skin and Cellular Biology Research(10), Genomics and Phylogenetic Studies(6)

Publications100 total

Human plasma proteomic profile of clonal hematopoiesis
Nature Communications·2025· 1 citedOpen Access
Abstract 4369178: Causal Proteomic Consequences of Clonal Hematopoiesis: Integrated Human Genetic and Murine Validation
Circulation·2025
<i>In vitro</i> models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of <scp>CRISPR</scp> perturbations
Molecular Oncology·2025Open Access
SPACE: multimodal spatial CRISPR screening with whole-transcriptome readout at subcellular resolution in 3D models
2025· 2 citedOpen Access
High-density extracellular recordings from the interior of intact brain organoids enable automated high-throughput functional assay
2025Open Access
PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension
American Journal of Respiratory Cell and Molecular Biology·2025· 3 citedOpen Access
Integrative analysis of single-cell transcriptomics and genetic associations identify cell states associated with vascular disease
Atherosclerosis·2025· 1 cited
Abstract B009: Characterization and CRISPR perturbation of cancer-associated fibroblast heterogeneity <i>in vitro</i> models
Cancer Research·2024
Abstract 4140254: Sex Influences Effects on Atherosclerosis in <i>TET2</i> -related Clonal Hematopoiesis of Indeterminate Potential and on Interleukin-1β Inhibition in Mice
Circulation·2024
Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function
Frontiers in Cell and Developmental Biology·2024· 6 citedOpen Access
Convergence of coronary artery disease genes onto endothelial cell programs
Nature·2024· 86 citedOpen Access
Human Plasma Proteomic Profile of Clonal Hematopoiesis
2023· 5 citedOpen Access
Polygenic prediction of preeclampsia and gestational hypertension
Nature Medicine·2023· 107 citedOpen Access
Genome-wide meta-analysis identifies novel maternal risk variants and enables polygenic prediction of preeclampsia and gestational hypertension
2022· 3 citedOpen Access
Abstract 14675: High-Throughput CRISPR Screening Links CAD Loci to Endothelial Cell Programs and Causal Pathways
Circulation·2022
Mapping the convergence of genes for coronary artery disease onto endothelial cell programs
2022· 9 citedOpen Access
Pink1 Deficiency Enhances Pulmonary Vascular Remodeling and Aggravates Hypoxia-Induced Pulmonary Hypertension
2022
Endothelial cell-specific deletion of a microRNA accelerates atherosclerosis
Atherosclerosis·2022· 17 citedOpen Access
Deep learning enables genetic analysis of the human thoracic aorta
Nature Genetics·2021· 193 citedOpen Access
Abstract 11265: Sex-Specific Response to Endothelin-1 Overexpression Mediates Thoracic Aortic Aneurysm Development
Circulation·2021
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Frequent Co-authors

Sridhar Sivasubbu(39), Vinod Scaria(36), Ankit Verma(19), Rijith Jayarajan(18), Rajat M. Gupta(10), Ashok Patowary(7), Ambily Sivadas(7), Vishal Dixit(6), Meghna Singh(5), Paras Sehgal(5), Stephen J. Fleming(4), J Engreitz(4), Patrick T. Ellinor(4), Rowmika Ravi(4), Ayshwarya Subramanian(3), Dejan Juric(3), James R. Stone(3), Shi Fang(3), Ramcharan Singh Angom(3), Mukesh Kumar Lalwani(3)