Timothy A. Springer

Boston Children's Hospital — United States

Medicine · Health Sciences

165h-index110.1kcitations732works6.72yr avg
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Research Topics

Cell Adhesion Molecules Research(404), Monoclonal and Polyclonal Antibodies Research(244), Platelet Disorders and Treatments(113), Glycosylation and Glycoproteins Research(93), T-cell and B-cell Immunology(79)

Publications732 total

A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
Nature Biotechnology·2025· 1 citedOpen Access
Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations
Journal of Biological Chemistry·2025· 6 citedOpen Access
De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties
Advanced Materials·2025· 1 citedOpen Access
High-Throughput Machine Learning-Aided Antibody Discovery for Cell Surface Antigens
2025· 1 citedOpen Access
BPS2025 - Understanding mechanical stability of integrin-ligand interactions under force at the single-molecule level
Biophysical Journal·2025
BPS2025 - Integrins: Environment recognition machines activated by ligand binding and actin pulling
Biophysical Journal·2025
De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine
2024· 2 citedOpen Access
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits
mAbs·2024· 5 citedOpen Access
Ligand binding initiates single-molecule integrin conformational activation
Cell·2024· 50 citedOpen Access
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits
2024· 1 citedOpen Access
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
Nature Communications·2023· 36 citedOpen Access
Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii
Communications Biology·2023· 4 citedOpen Access
Conformational change of <i>Plasmodium</i> <scp>TRAP</scp> is essential for sporozoite migration and transmission
EMBO Reports·2023· 14 citedOpen Access
<i>De novo</i> design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
2023· 2 citedOpen Access
A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding
Journal of Biological Chemistry·2023· 9 citedOpen Access
A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8
Proceedings of the National Academy of Sciences·2023· 16 citedOpen Access
Structural insights into MIC2 recognition by MIC2-associated protein
2023Open Access
Inhaled Therapeutic for Idiopathic Pulmonary Fibrosis Reduces Fibrotic Biomarkers in Mouse Model
2023
Supplementary Figure from Loss of LRRC33-Dependent TGFβ1 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy
2023Open Access
Supplementary Figure from Loss of LRRC33-Dependent TGFβ1 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy
2023Open Access
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Frequent Co-authors

Michael L. Dustin(11), Donald E. Staunton(6), Steven D. Marlin(4), Robert Rothlein(3), Christopher V. Carman(3), Conrad C. Bleul(3), José Carlos Gutierrez‐Ramos(3), Junichi Takagi(3), Michael Diamond(3), Francisco Sánchez‐Madrid(3), E. Robbins(3), Qing Ma(2), Dan Jones(2), Alessandro Aiuti(2), Michelle Woldemar Carr(2), Thomas Walz(2), G. Galfré(2), David S. Secher(2), César Milstein(2), Martin E. Sanders(2)