Alan J. Grodzinsky

Massachusetts Institute of Technology — United States

Medicine · Health Sciences

98h-index34.6kcitations491works1.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Osteoarthritis Treatment and Mechanisms(304), Knee injuries and reconstruction techniques(101), Proteoglycans and glycosaminoglycans research(66), Cell Adhesion Molecules Research(55), Lower Extremity Biomechanics and Pathologies(43)

Publications490 total

MMP release following cartilage injury leads to collagen loss in intact tissue: A computational study
PLoS Computational Biology·2026Open Access
Cationic Dendrimer Nanoformulation Improves Therapeutic Efficacy of Pro-Anabolic and Anti-Catabolic Therapeutics in Osteoarthritis
Regenerative Engineering and Translational Medicine·2026Open Access
Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content
PLoS Computational Biology·2025Open Access
The Effect of IL-17A and Combined Mechanical Injury on Meniscal Tissue Integrity In Vitro
Journal of Clinical Medicine·2025Open Access
Investigating Bio-Nano Interactions of PEGylated Cationic Polyamidoamine (PAMAM) Dendrimers within Synovial Joints
2025Open Access
MMP release following cartilage injury leads to collagen loss in intact tissue – a computational study
2025Open Access
ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease
Nature Biomedical Engineering·2025· 1 cited
Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage
Biomechanics and Modeling in Mechanobiology·2025· 3 citedOpen Access
Understanding the role of PEGylation on PAMAM’s drug delivery properties to articular cartilage
SSRN Electronic Journal·2025Open Access
Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content
2024· 3 citedOpen Access
Loss of collagen content is localized near cartilage lesions on the day of injurious loading and intensified on day 12
Journal of Orthopaedic Research®·2024· 4 citedOpen Access
Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage
2024Open Access
Effects of dexamethasone and IGF-1 on post-traumatic osteoarthritis-like catabolic changes in a human cartilage-bone-synovium microphysiological system in space and ground control tissues on earth
Frontiers in Space Technologies·2024· 2 citedOpen Access
The effect of IL-17A and combined mechanical injury on meniscal tissue integrity in vitro
Research Square (Research Square)·2023Open Access
Poroelastic behavior and water permeability of human skin at the nanoscale
PNAS Nexus·2023· 8 citedOpen Access
486 Macroscale Forces Drive Targetable Microscale Fibrotic Mechanosensing in Degenerative Spinal Disease
Neurosurgery·2023
Effects of dexamethasone and dynamic loading on cartilage of human osteochondral explants challenged with inflammatory cytokines
Journal of Biomechanics·2023· 5 cited
Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines
PLoS Computational Biology·2023· 22 citedOpen Access
Loss of Collagen Content is Localized Near Cartilage Lesions on the Day of Injurious Loading and Intensified on Day 12
SSRN Electronic Journal·2023Open Access
Charge shielding effects of PEG bound to NH<sub>2</sub>-terminated PAMAM dendrimers – an experimental approach
Soft Matter·2023· 23 citedOpen Access
page 1 of 25Next →

Frequent Co-authors

Eliot H. Frank(8), Moonsoo M. Jin(6), Bodo Kurz(5), Michael D. Buschmann(5), Ernst B. Hunziker(5), Robert L. Sah(3), John D. Kisiday(3), John D. Sandy(3), Gordana Vunjak‐Novakovic(3), Iván Martín(3), S. Treppo(3), Lisa E. Freed(3), Roger D. Kamm(3), Richard Lee(3), Hadi T. Nia(3), Jonathan B. Fitzgerald(3), Young Jo Kim(2), Joe‐Yuan H. Doong(2), Shuguang Zhang(2), Yehezkiel A. Gluzband(2)