Christiane Guguen‐Guillouzo

Inserm — France

Medicine · Health Sciences

58h-index13.2kcitations225works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Liver physiology and pathology(73), Drug Transport and Resistance Mechanisms(40), Liver Disease Diagnosis and Treatment(37), Pancreatic function and diabetes(31), Drug-Induced Hepatotoxicity and Protection(28)

Publications225 total

Extended lifespan and improved genome stability in HepaRG-derived cell lines through reprogramming by high-density stress
Proceedings of the National Academy of Sciences·2023· 7 citedOpen Access
In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes
Cells·2019· 70 citedOpen Access
Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential
Toxicological Sciences·2019· 13 citedOpen Access
Changes in bile acid profiles induced by cholestatic drugs in HepaRG hepatocytes cultured in bile acid-enriched medium
HAL (Le Centre pour la Communication Scientifique Directe)·2019
Setup and Use of HepaRG Cells in Cholestasis Research
Methods in molecular biology·2019· 8 cited
Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system
Scientific Reports·2018· 74 citedOpen Access
HepaRG Cells as a Model for Hepatotoxicity Studies
2018· 11 cited
Use of a reliable metabolically competent human RGHep+ hepatocyte model engineered with biological tracers for in vitro micronucleus test associating high-content imaging
Drug Metabolism and Pharmacokinetics·2018
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
Free Radical Biology and Medicine·2017· 61 cited
Antibiotic-induced cytotoxicity and cholestasis are related to an endoplasmic reticulum stress and amplified by inflammatory cytokines in human hepatocytes
Toxicology Letters·2017
Cholestatic drugs induce preferential accumulation of toxic bile acids in human HepaRG cells
Toxicology Letters·2017
Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation
Drug Metabolism and Disposition·2017· 25 citedOpen Access
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways
Scientific Reports·2017· 25 citedOpen Access
From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells
Toxicological Sciences·2017· 16 citedOpen Access
Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α
Toxicology Letters·2016· 23 citedOpen Access
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs
Scientific Reports·2016· 97 citedOpen Access
Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors
European Journal of Medicinal Chemistry·2016· 18 citedOpen Access
Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix
Experimental Cell Research·2016· 27 citedOpen Access
Functional polymer‐dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes
Hepatology Research·2016· 58 citedOpen Access
Selective bile canalicular changes induced by cholestatic drugs
Toxicology Letters·2015· 1 cited
page 1 of 12Next →

Frequent Co-authors

Denise Glaise(17), André Guillouzo(15), Philippe Gripon(10), Georges Baffet(8), Anne Corlu(7), Pascal Loyer(6), Jacques Le Seyec(5), A. Guillouzo(5), Ruoya Li(5), Fabrice Morel(4), Christophe Chesné(4), Sylvie Rumin(3), Isabelle Cannie(3), Caroline Aninat(3), Delphine Garnier(3), Sébastien Anthérieu(3), Claude Rescan(3), David Gilot(3), Julie Dumont(3), Audrey Burban(3)