Karina Hougen

Oslo University Hospital — Norway

Medicine · Health Sciences

11h-index507citations21works0.02yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(17), Ion channel regulation and function(11), Neuroscience and Neural Engineering(6), Heart Failure Treatment and Management(5), Phosphodiesterase function and regulation(4)

Publications21 total

Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation·2023· 20 cited
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Frontiers in Cardiovascular Medicine·2021· 6 citedOpen Access
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovascular Research·2019· 28 cited
Abstract 19852: PDE3A Binds Directly to and Inhibits SERCA2 Activity Independently of its Catalytic Activity
Circulation·2017
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
European Journal of Pharmacology·2017· 34 cited
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS ONE·2016· 11 citedOpen Access
Hypokalaemia induces Ca<sup>2+</sup> overload and Ca<sup>2+</sup> waves in ventricular myocytes by reducing Na<sup>+</sup>,K<sup>+</sup>‐ATPase α<sub>2</sub> activity
The Journal of Physiology·2014· 52 citedOpen Access
The Effect of Exercise Training on Ca2+ Wave Probability After Myocardial Infarction Depends on Cardiac Function at Onset of Training.
Heart Rhythm·2013
<scp>SERCA</scp>2 activity is involved in the <scp>CNP</scp>‐mediated functional responses in failing rat myocardium
British Journal of Pharmacology·2013· 28 citedOpen Access
I CaL inhibition prevents arrhythmogenic Ca2+ waves caused by abnormal Ca2+ sensitivity of RyR or SR Ca2+ accumulation
Cardiovascular Research·2013· 10 citedOpen Access
Slow Ca2+ sparks de-synchronize Ca2+ release in failing cardiomyocytes: Evidence for altered configuration of Ca2+ release units?
Journal of Molecular and Cellular Cardiology·2013· 64 cited
Abstract 16425: Slow Ca2+ Sparks De-synchronize Ca2+ Release in Failing Cardiomyocytes: Evidence for Altered Ryanodine Receptor Distribution?
Circulation·2012
IP3 Receptors in Heart Failure: Arrhythmogenic Troublemakers or SR Calcium Security Valves?
Biophysical Journal·2012· 1 citedOpen Access
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(αMHC-MerCreMer) mice
American Journal of Physiology-Heart and Circulatory Physiology·2010· 36 cited
Alterations in Ca2+ Sparks and T-Tubules Promote Slowed, Dyssynchronous Ca2+ Release in Failing Cardiomyocytes
Biophysical Journal·2010Open Access
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovascular Research·2009· 56 citedOpen Access
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following<i>Serca2</i>knockout
The Journal of Physiology·2009· 94 citedOpen Access
Natriuretic peptides increase β1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition
Cardiovascular Research·2009· 65 cited
Ca2+ Wave Development in Ventricular Cardiomyocytes from Mice with Inducible Knockout of SERCA2
Biophysical Journal·2009· 1 citedOpen Access
Abstract 5307: Cardiomyocyte Sodium Accumulation Promotes Diastolic Dysfunction in Serca2 Knockout Mice
Circulation·2008
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Frequent Co-authors

Ivar Sjaastad(21), Ole M. Sejersted(15), Jan Magnus Aronsen(13), William E. Louch(12), Mathis K. Stokke(10), Geir Christensen(7), Halvor K. Mørk(6), Kristin B. Andersson(6), Fredrik Swift(5), Finn Olav Levy(4), Jonas Skogestad(4), Eirik Qvigstad(3), Lise Román Moltzau(3), Tor Skomedal(3), Cathrine R. Carlson(3), Mani Sadredini(3), Tore Kristian Danielsen(3), Ravinea Manotheepan(3), Cam H.T. Nguyen(2), Jan‐Bjørn Osnes(2)