Philip V. LoGrasso

Scripps Research Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index4.7kcitations93works0.02yr avg
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Research Topics

Melanoma and MAPK Pathways(53), Protein Kinase Regulation and GTPase Signaling(29), Synthesis and biological activity(18), Computational Drug Discovery Methods(11), Cytokine Signaling Pathways and Interactions(9)

Publications93 total

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease
Proceedings of the National Academy of Sciences·2018· 217 citedOpen Access
Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin’s Anorectic Signaling Actions
Scientific Reports·2017· 29 citedOpen Access
Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives
Journal of Medicinal Chemistry·2016· 1 cited
Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential
Journal of Medicinal Chemistry·2015· 367 citedOpen Access
Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in <i>In Vivo</i> Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway
Molecular and Cellular Biology·2015· 21 citedOpen Access
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors
ACS Medicinal Chemistry Letters·2015· 29 citedOpen Access
Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles
Scientific Reports·2015· 30 citedOpen Access
Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors
Journal of Medicinal Chemistry·2015· 58 citedOpen Access
Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives
Journal of Medicinal Chemistry·2014· 63 citedOpen Access
JNK2/3 in complex with N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide
2014
JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
2014
Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 21 citedOpen Access
Rho kinase inhibitors: a patent review (2012 – 2013)
Expert Opinion on Therapeutic Patents·2013· 44 cited
c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis
2013
A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases
ACS Chemical Biology·2013· 20 citedOpen Access
Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors
Journal of Medicinal Chemistry·2013· 36 citedOpen Access
Synthesis of Benzoquinone Ansamycin‐Inspired Macrocyclic Lactams from Shikimic Acid
Angewandte Chemie·2013· 5 cited
Synthesis of Benzoquinone Ansamycin‐Inspired Macrocyclic Lactams from Shikimic Acid
Angewandte Chemie International Edition·2013· 24 cited
Amino acid derived quinazolines as Rock/PKA inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 16 citedOpen Access
Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats
Journal of Biological Chemistry·2012· 79 citedOpen Access
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Frequent Co-authors

Yangbo Feng(15), Michael D. Cameron(13), Thomas Schröter(12), Claudia Ruiz(11), Lin Li(9), Yan Yin(8), Stephan C. Schürer(8), Jeremy W. Chambers(7), Derek R. Duckett(7), Jennifer Pocas(7), Shannon Howard(6), Amiee Weiser(6), Wayne Grant(6), HaJeung Park(5), Evelyn Griffin(5), John D. Laughlin(4), Betsy Frantz(4), Thomas D. Bannister(4), Alok S. Pachori(4), Jeff E. Habel(4)