David Lagorce

Inserm — France

Computer Science · Physical Sciences

30h-index5.3kcitations53works3.52yr avg
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Research Topics

Computational Drug Discovery Methods(22), Genomics and Rare Diseases(11), Microbial Natural Products and Biosynthesis(9), Protein Structure and Dynamics(6), Hepatitis B Virus Studies(6)

Publications51 total

Combining phenotypic similarity and network propagation to improve performance and clinical consistency of rare disease diagnosis
2026Open Access
Mondo: integrating disease terminology across communities
Genetics·2025· 5 citedOpen Access
The Orphanet Nomenclature of rare diseases: a standard terminology for improved patient recognition and data interoperability
2025· 1 citedOpen Access
The Human Phenotype Ontology in 2024: phenotypes around the world
Nucleic Acids Research·2023· 314 citedOpen Access
Phenotypic similarity-based approach for variant prioritization for unsolved rare disease: a preliminary methodological report
European Journal of Human Genetics·2023· 12 citedOpen Access
Phenotypic similarity-based approach for variant prioritization for unsolved rare disease: a preliminary methodological report
Research Square (Research Square)·2023Open Access
Mondo: Unifying diseases for the world, by the world
2022· 97 citedOpen Access
Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases
European Journal of Human Genetics·2021· 100 citedOpen Access
The Human Phenotype Ontology in 2021
Nucleic Acids Research·2020· 1.2k citedOpen Access
Fr-PPIChem: An Academic Compound Library Dedicated to Protein–Protein Interactions
ACS Chemical Biology·2020· 43 citedOpen Access
FAF-Drugs4: free ADME-tox filtering computations for chemical biology and early stages drug discovery
Bioinformatics·2017· 309 citedOpen Access
In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening
Scientific Reports·2017· 15 citedOpen Access
Pan-assay interference compounds (PAINS) that may not be too painful for chemical biology projects
Drug Discovery Today·2017· 40 cited
Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
Scientific Reports·2017· 245 citedOpen Access
iPPI-DB: an online database of modulators of protein–protein interactions
Nucleic Acids Research·2015· 56 citedOpen Access
In Silico Approaches Assisting the Rational Design of Low Molecular Weight Protein–Protein Interaction Modulators
2015
FAF-Drugs3: a web server for compound property calculation and chemical library design
Nucleic Acids Research·2015· 273 citedOpen Access
MTiOpenScreen: a web server for structure-based virtual screening
Nucleic Acids Research·2015· 277 citedOpen Access
In silico design of low molecular weight protein–protein interaction inhibitors: Overall concept and recent advances
Progress in Biophysics and Molecular Biology·2015· 57 cited
Rational Design of Small-Molecule Stabilizers of Spermine Synthase Dimer by Virtual Screening and Free Energy-Based Approach
PLoS ONE·2014· 29 citedOpen Access
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Frequent Co-authors

Maria A. Miteva(30), Bruno O. Villoutreix(28), Olivier Spérandio(15), Marc Hanauer(7), Céline M. Labbé(7), Ana Rath(6), Christian Bréchot(6), Sebastian Köhler(5), Peter N. Robinson(5), Caterina Lucano(5), Nicolas Matentzoglu(4), Tiffany J. Callahan(4), Patrizia Paterlini-Bréchot(4), Mounia Chami(4), Mélaine A. Kuenemann(4), Sergi Beltrán(4), Tania Pencheva(4), Virginie Martiny(4), Leigh Carmody(3), Nicole Vasilevsky(3)