Wei Lemaire

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Neuroscience · Life Sciences

22h-index2.3kcitations42works0.02yr avg
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Research Topics

Sleep and Wakefulness Research(12), Neuroscience and Neuropharmacology Research(10), Sleep and related disorders(10), Circadian rhythm and melatonin(7), Receptor Mechanisms and Signaling(7)

Publications42 total

Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections
ACS Medicinal Chemistry Letters·2023· 1 citedOpen Access
Virtual screening for early identification of potent and selective histone deacetylase 6 inhibitor series
Bioorganic & Medicinal Chemistry Letters·2023
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease
ACS Medicinal Chemistry Letters·2023· 11 citedOpen Access
Virtual Screening for Early Identification of Potent and Selective Histone Deacetylase 6 Inhibitor Series
SSRN Electronic Journal·2023Open Access
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy
Neurobiology of Disease·2021· 20 citedOpen Access
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction
ACS Medicinal Chemistry Letters·2021· 18 citedOpen Access
Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5
SLAS DISCOVERY·2016· 10 citedOpen Access
CCDC 1445355: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements
Bioorganic & Medicinal Chemistry Letters·2015· 16 citedOpen Access
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant
Bioorganic & Medicinal Chemistry Letters·2014· 22 citedOpen Access
Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
Bioorganic & Medicinal Chemistry Letters·2014· 28 citedOpen Access
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis
Bioorganic & Medicinal Chemistry Letters·2014· 10 citedOpen Access
Cover Picture: Discovery of 5′′‐Chloro‐<i>N</i>‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia (ChemMedChem 2/2014)
ChemMedChem·2014Open Access
Discovery of 5′′‐Chloro‐<i>N</i>‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia
ChemMedChem·2013· 65 cited
Benzimidazole CB2 agonists: Design, synthesis and SAR
Bioorganic & Medicinal Chemistry Letters·2013· 23 citedOpen Access
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)
Bioorganic & Medicinal Chemistry Letters·2013· 24 citedOpen Access
Cover Picture: Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties (ChemMedChem 3/2012)
ChemMedChem·2012· 4 cited
Corrigendum to “Development of a scintillation proximity assay for analysis of Na+/Cl− -dependent neurotransmitter transporter activity” [Anal. Biochem. 321 (2003) 31–37]
Analytical Biochemistry·2012
Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties
ChemMedChem·2012· 121 cited
CCDC 857980: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
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Frequent Co-authors

George D. Hartman(20), Paul J. Coleman(16), Thomayant Prueksaritanont(15), David L. Williams(15), C. Meacham Harrell(14), Susan L. Garson(14), Christopher J. Winrow(14), John J. Renger(14), Cyrille Sur(14), Tamara D. Cabalu(12), Donghui Cui(12), Craig W. Lindsley(12), Anthony J. Roecker(11), Douglas J. Pettibone(11), Julie A. O’Brien(10), Marlene A. Jacobson(10), P. Jeffrey Conn(10), Steven V. Fox(10), Anthony L. Gotter(10), Christopher D. Cox(9)