Andrew T. Pudzianowski

Bristol-Myers Squibb (United States) — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

19h-index915citations51works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(8), Crystallization and Solubility Studies(7), X-ray Diffraction in Crystallography(7), Metal-Catalyzed Oxygenation Mechanisms(5), Advanced Chemical Physics Studies(4)

Publications51 total

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity
Bioorganic & Medicinal Chemistry Letters·2017· 38 citedOpen Access
CCDC 1586093: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1586094: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1586092: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Correction to “Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development”
The Journal of Organic Chemistry·2015· 3 citedOpen Access
Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development
The Journal of Organic Chemistry·2015· 29 cited
CCDC 1420747: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1420748: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Aroylguanidine-based factor Xa inhibitors: The discovery of BMS-344577
Bioorganic & Medicinal Chemistry Letters·2009· 24 citedOpen Access
Mechanistic studies of addition of nucleophiles to arene oxides and diol epoxides: Candidate ultimate carcinogens
International Journal of Quantum Chemistry·2009· 4 cited
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 18 citedOpen Access
Design, Structure−Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors
Journal of Medicinal Chemistry·2008· 35 citedOpen Access
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 50 citedOpen Access
Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series
Bioorganic & Medicinal Chemistry Letters·2006· 48 citedOpen Access
Erratum to “Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors” [Bioorg. Med. Chem. Lett. 15 (2005) 5453–5458]
Bioorganic & Medicinal Chemistry Letters·2005· 1 cited
Initial Structure-Activity Relationships for a Caprolactam-based Series of Neutral Factor Xa Inhibitors: Lead Identification
Letters in Drug Design & Discovery·2005· 8 cited
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors
Bioorganic & Medicinal Chemistry Letters·2005· 18 citedOpen Access
Structure‐Based Design of Potent and Selective Inhibitors of Collagenase‐3 (MMP‐13).
ChemInform·2005· 1 cited
A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes
Bioorganic & Medicinal Chemistry Letters·2005· 9 cited
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)
Bioorganic & Medicinal Chemistry Letters·2005· 93 citedOpen Access
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Frequent Co-authors

Gilda H. Loew(13), Philip D. Stein(9), Jack Z. Gougoutas(7), Dauh‐Rurng Wu(7), Karnail S. Atwal(7), Sharon N. Bisaha(7), Mary F. Malley(6), Doree Sitkoff(6), Karen S. Hartl(6), Thomas E. Steinbacher(6), Joel C. Barrish(5), Yan Shi(5), William A. Schumacher(5), Hossain Monshizadegan(5), Patricia A. McDonnell(4), Scott A. Shaw(4), Balu Balasubramanian(4), Samuel J. Bonacorsi(4), Janet Caceres‐Cortes(4), Kevin Cao(4)