Anna Scotto Rosato

Ludwig-Maximilians-Universität München — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index2.4kcitations21works13.02yr avg
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Research Topics

Calcium signaling and nucleotide metabolism(20), Ion Channels and Receptors(7), Cellular transport and secretion(6), Lysosomal Storage Disorders Research(5), Autophagy in Disease and Therapy(3)

Publications21 total

Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis
Nature Communications·2024· 15 citedOpen Access
TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
Scientific Reports·2024· 11 citedOpen Access
TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
2023· 1 citedOpen Access
Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!
Cells·2022· 25 citedOpen Access
<scp>TPC2</scp> rescues lysosomal storage in mucolipidosis type <scp>IV</scp> , <scp>Niemann–Pick</scp> type <scp>C1,</scp> and Batten disease
EMBO Molecular Medicine·2022· 39 citedOpen Access
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
Nature Communications·2022· 28 citedOpen Access
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?
Cell Calcium·2022· 27 cited
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice
Nature Communications·2022· 69 citedOpen Access
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
EMBO Molecular Medicine·2021· 44 citedOpen Access
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2
Scientific Reports·2021· 61 citedOpen Access
Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors
Scientific Reports·2021· 43 citedOpen Access
Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis
Pharmacology & Therapeutics·2020· 50 cited
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
eLife·2020· 150 citedOpen Access
Author response: Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
2020· 1 citedOpen Access
TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
Nature Communications·2019· 180 citedOpen Access
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells
eLife·2018· 101 citedOpen Access
Author response: Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells
2018· 3 citedOpen Access
Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV
Human Molecular Genetics·2018· 32 citedOpen Access
TRPML1: Role In Autophagy And Potential Target To Treat Lysosomal Storage Disorders
Open Research Online (The Open University)·2018Open Access
TRPML1: The Ca(2+)retaker of the lysosome
Cell Calcium·2017· 149 cited
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Frequent Co-authors

Christian Grimm(17), Einar Krogsaeter(9), Diego L. Medina(8), Martin Biel(8), Franz Bracher(8), Cheng‐Chang Chen(7), Christian Wahl‐Schott(7), Marco Keller(6), Angelika M. Vollmar(5), Rachel Tang(5), Carla Abrahamian(5), Sandro Montefusco(4), Thomas Gudermann(4), Karin Bartel(4), Simone Di Paola(3), Maria Antonietta De Matteis(3), Andrea Ballabio(3), Chiara Soldati(3), Susanne Gerndt(3), Yu‐Kai Chao(3)