Steven L. Highfill

National Institutes of Health — United States

Medicine · Health Sciences

30h-index5.3kcitations202works3.52yr avg
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Research Topics

CAR-T cell therapy research(122), Immune Cell Function and Interaction(37), Immune cells in cancer(34), Virus-based gene therapy research(28), Viral Infectious Diseases and Gene Expression in Insects(27)

Publications202 total

Ten-year experience of CD22 CAR T cells for children and young adults with B-cell acute lymphoblastic leukemia
Blood Advances·2025Open Access
Supplementary Data DS1 from Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial
2025Open Access
Supplementary figures and tables FTS1 from Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial
2025Open Access
From bench to IND: Validation of TSLPR CAR T-cells reveal discrepancies in detection modalities and inform dose selection for a Phase 1 clinical trial in relapsed/refractory CRLF2-rearranged B-ALL patients.
Blood·2025
CD19/22 CAR T-cells in children and young adults with B-ALL: Final Phase 1 trial results
Blood·2025
506 Immune cell composition analysis of ERVE-4 T-Cell receptor gene therapy infusion products in metastatic ccRCC: insights from a first-in-human trial
Regular and Young Investigator Award Abstracts·2025Open Access
351 Development of human genetically engineered myeloid cells (GEMys) for first-in-human clinical trial
Regular and Young Investigator Award Abstracts·2025Open Access
Outcomes following CD22 CAR T-cells in B-ALL: a tale of two manufacturing strategies
Cytotherapy·2025Open Access
Correction: Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study
Blood Cancer Journal·2025Open Access
Engineering Next-Generation Mesothelin CAR-T cells by Harnessing Naïve and Early Memory T cells
Cytotherapy·2025
Exploring Innovative Approaches to Hematopoietic Progenitor Cell Selection Using Automated Methods
Cytotherapy·2025
Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study
Blood Cancer Journal·2025· 7 citedOpen Access
Assessing the impact of cell isolation method on B cell gene expression using next-generation sequencing
Experimental Hematology·2025· 1 citedOpen Access
Immunophenotype of CAR T cells and apheresis products predicts response in CD22 CAR T cell trial for B cell acute lymphoblastic leukemia
Molecular Therapy·2025· 7 cited
Talicabtagene autoleucel for relapsed or refractory B-cell malignancies: results from an open-label, multicentre, phase 1/2 study
The Lancet Haematology·2025· 8 cited
Differential Gene Expression Analysis Indicates Elevated Presence of Terminal Effector T-Cells in CD22 CAR T-Cell Infusion Products from B-Cell Acute Lymphoblastic Leukemia (B-ALL) Patients with High Baseline Bone Marrow (BM) Disease Burden
Transplantation and Cellular Therapy·2025
Dendritic Cell Cancer Vaccines: A Focused Review
Methods in molecular biology·2025· 3 cited
Dendritic Cell Cancer Vaccines: Clinical Production for Cancer Immunotherapy
Methods in molecular biology·2025· 2 cited
Efficient manufacturing of CAR-T cells from whole blood: a scalable approach to reduce costs and enhance accessibility in cancer therapy
Cytotherapy·2024· 6 citedOpen Access
Initial Experience with CD19/CD22 BiCistronic CAR T-Cells in Children and Young Adults with Recurrent or Refractory B-Cell Malignancies
Blood·2024· 2 citedOpen Access
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Frequent Co-authors

David F. Stroncek(29), Ping Jin(13), Sandhya R. Panch(12), Nirali N. Shah(11), Crystal L. Mackall(10), Terry J. Fry(9), Bruce R. Blazar(7), Constance M. Yuan(7), Lipei Shao(7), Jianjian Jin(6), Hao‐Wei Wang(6), James N. Kochenderfer(6), Robert Somerville(6), Haneen Shalabi(5), Bonnie Yates(5), Maryalice Stetler‐Stevenson(5), Nikolaos Gkitsas(5), Rongye Shi(5), Yihua Cai(5), Rosandra N. Kaplan(4)