David A. Largaespada

University of Minnesota — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

68h-index25.1kcitations650works0.82yr avg
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Research Topics

CRISPR and Genetic Engineering(92), RNA modifications and cancer(76), Neurofibromatosis and Schwannoma Cases(70), Acute Myeloid Leukemia Research(66), Epigenetics and DNA Methylation(63)

Publications644 total

Non-viral TcBuster transposon engineering of CD70-CAR natural killer cells for the treatment of osteosarcoma
Molecular Therapy Oncology·2025Open Access
A new framework for engaging patients and the public in basic cancer research
Nature reviews. Cancer·2025
Functional genomics for improving adoptive T-cell transfer therapies
Journal for ImmunoTherapy of Cancer·2025Open Access
TMIC-23. Glioblastoma subtype influences overall survival and migration of glioblastoma cells and T cells in synegeneic mouse models and are modeled with a novel Brownian Dynamics Tumor Simulator (BDTS)
Neuro-Oncology·2025Open Access
EXTH-124. Advancing Cellular Immunotherapy for NF1-Associated MPNST: Novel Targets, Immune-Competent Models, and Small Molecule Combination Approaches
Neuro-Oncology·2025Open Access
RBIO-19. Radiation-Mediated MDSC Immunodynamics in Recurrent High-Grade Glioma
Neuro-Oncology·2025Open Access
DDDR-42. Modeling and Translating Precision Therapies for NF1-Associated Tumors Across the Disease Spectrum
Neuro-Oncology·2025Open Access
P14.22.A A NOVEL IMMUNOCOMPETENT ORTHOTOPIC MOUSE MODEL TO STUDY EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMRS): DEVELOPMENT AND CHARACTERIZATION
Neuro-Oncology·2025Open Access
Pharmacogenomic Synthetic Lethal Screens Reveal Hidden Vulnerabilities and New Therapeutic Approaches for Treatment of NF1-Associated Tumors
Molecular Cancer Therapeutics·2025· 1 citedOpen Access
<i>Sleeping Beauty</i> mutagenesis identifies <i>BACH2</i> and other regulators of CD8 <sup>+</sup> T cell exhaustion, persistence <i>in vivo</i> , and CAR-T function under tumor-associated chronic antigen stimulation
2025· 1 citedOpen Access
CREB5 promotes tumorigenicity and upregulates druggable cell surface modalities in basal-like breast cancer
npj Precision Oncology·2025· 1 citedOpen Access
A modular, immunopeptidogenomic (iPepGen) analysis pipeline for discovery, verification, and prioritization of cancer peptide neoantigen candidates
2025Open Access
Techniques for Validating CRISPR Changes Using RNA-Sequencing Data
Genes·2025Open Access
Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements
2025· 1 citedOpen Access
DEAPR: Differential Expression and Pathway Ranking Tool Demonstrates NRASG12V and NRASG12D Mutations Have Differing Effects in THP-1 Cells
Cancers·2025· 1 citedOpen Access
A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance
Developmental Cell·2025· 2 cited
Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination
Biomolecules·2025· 1 citedOpen Access
433 <i>Sleeping Beauty</i> mutagenesis uncovers crucial role of Bach2 in resisting chronic tumor stimulation in CD8<sup>+</sup> T cells
Regular and Young Investigator Award Abstracts·2024Open Access
244 A phase 1 study of novel transposon-based BAFF CAR-T cells (LMY-920) for treatment of relapsed or refractory non-hodgkin lymphoma (NHL)
Regular and Young Investigator Award Abstracts·2024· 2 citedOpen Access
Cell type specific suppression of hyper-recombination by human RAD18 is linked to PCNA K164 ubiquitination
2024Open Access
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Frequent Co-authors

Neal G. Copeland(16), Nancy A. Jenkins(14), Adam J. Dupuy(12), Perry B. Hackett(10), Branden S. Moriarity(9), Aaron L. Sarver(8), Timothy K. Starr(7), R. Scott McIvor(6), Walter C. Low(4), Takuro Nakamura(4), Lara S. Collier(4), Corey M. Carlson(4), Stephen C. Ekker(4), Eric P. Rahrmann(4), Natalie K. Wolf(4), Vincent W. Keng(4), Joel L. Frandsen(4), George M. Otto(3), Maeve O’Sullivan(3), John D. Shaughnessy(3)