Suren M. Zakian

Institute of Chemical Biology and Fundamental Medicine — Russia

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index3.1kcitations210works1.22yr avg
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Research Topics

Pluripotent Stem Cells Research(76), CRISPR and Genetic Engineering(73), Chromosomal and Genetic Variations(36), Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities(29), Animal Genetics and Reproduction(22)

Publications210 total

Functional and Expression Studies of iPSC-Derived Cardiomyocytes Carrying a Novel HCM-Associated MYPN Genetic Variant
Preprints.org·2025Open Access
Transcriptomic Analysis of TDP1-Knockout HEK293A Cells Treated with the TDP1 Inhibitor (Usnic Acid Derivative)
International Journal of Molecular Sciences·2025Open Access
Generating a Cell Model to Study ER Stress in iPSC-Derived Medium Spiny Neurons from a Patient with Huntington’s Disease
International Journal of Molecular Sciences·2025Open Access
Evaluation of Mitochondrial Activity in Neural iPSC Derivatives Obtained from a Parkinson’s Disease Patient with Genetic Variant C.1492T>G of GLUD2
Neurochemical Journal·2025
Generation of the ICGi019-B-1 and ICGi019-B-2 lines via correction of the p.Met659Ile (c.1977G>A) variant in MYH7 of patient-specific induced pluripotent stem cells using CRISPR/Cas9
Vavilov Journal of Genetics and Breeding·2025Open Access
Isogenic induced pluripotent stem cell line ICGi036-A-1 from a patient with familial hypercholesterolaemia, derived by correcting a pathogenic variant of the gene LDLR c.530C>T
Vavilov Journal of Genetics and Breeding·2025Open Access
Generation and characterisation of seven induced pluripotent stem cell lines from two patients with Parkinson’s disease carrying the pathological variant c.1087G>T of the LGR4 gene
Vavilov Journal of Genetics and Breeding·2025Open Access
Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy
Biomedicines·2025· 2 citedOpen Access
In vitro models of proteinopathy-associated neurodegenerative diseases
Vestnik Tomskogo gosudarstvennogo universiteta Biologiya·2025
Targeted editing of human induced pluripotent stem cells genomes as a tool for functional analysis of genetic variants
Vestnik Tomskogo gosudarstvennogo universiteta Biologiya·2025
Generation of Isogenic iPSC Lines for Studying the Effect of the p.N515del (c.1543_1545delAAC) Variant on MYBPC3 Function and Hypertrophic Cardiomyopathy Pathogenesis
International Journal of Molecular Sciences·2024Open Access
Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated with the pathological variant c.2013T>G in the MAPT gene
Vavilov Journal of Genetics and Breeding·2024· 2 citedOpen Access
Studying Pathogenetic Contribution of a Variant of Unknown Significance, p.M659I (c.1977G > A) in MYH7, to the Development of Hypertrophic Cardiomyopathy Using CRISPR/Cas9-Engineered Isogenic Induced Pluripotent Stem Cells
International Journal of Molecular Sciences·2024· 4 citedOpen Access
Generation of iPSCs from a Patient with the M694V Mutation in the MEFV Gene Associated with Familial Mediterranean Fever and Their Differentiation into Macrophages
International Journal of Molecular Sciences·2024· 2 citedOpen Access
Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the GBA1 Gene
Biomedicines·2024· 6 citedOpen Access
Effect of M694V mutation in the MEFV gene, associated with Familial Mediterranean fever, on the morphology of iPSC-derived macrophages
Preprints.org·2024Open Access
A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts
Cells·2024· 1 citedOpen Access
Generation of an Induced Pluripotent Stem Cell Line ICGi045-A of a RASopathy Patient Carrying p.Glu329Lys Variant in SOS1
Russian Journal of Developmental Biology·2024
iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial Hypercholesterolemia
International Journal of Molecular Sciences·2024· 5 citedOpen Access
IPSC-Derived Astrocytes Contribute to In Vitro Modeling of Parkinson’s Disease Caused by the GBA1 N370S Mutation
International Journal of Molecular Sciences·2023· 6 citedOpen Access
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Frequent Co-authors

S. P. Medvedev(22), Alexander I. Shevchenko(19), Tatyana B. Nesterova(15), Anastasia A. Malakhova(12), Eugeny A. Elisaphenko(9), Neil Brockdorff(8), N. A. Mazurok(8), Е. В. Григорьева(7), Evgeny Pokushalov(6), И. С. Захарова(6), Tuyana Malankhanova(6), Igor B. Rogozin(5), С. В. Павлова(5), Elena Vladimirovna Dementyeva(4), K. R. Valetdinova(3), Sergey Ya. Slobodyanyuk(3), Н. Б. Рубцов(3), Nadezhda V. Rubtsova(3), Nadezhda S. Dyrkheeva(3), Alexandra L. Zakharenko(3)