David Holcman

Collège de France — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index8.6kcitations397works2.22yr avg
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Research Topics

Diffusion and Search Dynamics(108), stochastic dynamics and bifurcation(62), Neural dynamics and brain function(53), Neuroscience and Neuropharmacology Research(49), Genomics and Chromatin Dynamics(43)

Publications396 total

Cortico-thalamic excitatory-inhibitory dynamics generates <i>α</i> -wave transient patterns encoding anesthetic brain states
2025
WEAKLY SUPERVISED SEGMENTATION AND CLASSIFICATION OF ALPHA-SYNUCLEIN AGGREGATES IN BRIGHTFIELD MIDBRAIN IMAGES.
PubMed·2025
Forecasting Excessive Anesthesia Depth Using EEG α-Spindle Dynamics and Machine Learning
arXiv (Cornell University)·2025Open Access
Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
2025Open Access
Assessing One-Dimensional Cluster Stability by Extreme-Point Trimming
arXiv (Cornell University)·2025Open Access
Column-Like Subnetwork Reconstruction in Motor Cortex from Graph-Based 3D High-Density Two-Photon Calcium Imaging
2025
How should clinicians interpret these results?
European Journal of Anaesthesiology·2025· 1 cited
Insulation between adjacent TADs is controlled by the width of their boundaries through distinct mechanisms
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation
2025· 3 citedOpen Access
Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics
Nature Communications·2025· 6 citedOpen Access
Unveiling the functional connectivity of astrocytic networks with AstroNet, a graph reconstruction algorithm coupled to image processing
Communications Biology·2025· 3 citedOpen Access
Voltage laws in nanodomains revealed by asymptotics and simulations of electro-diffusion equations
arXiv (Cornell University)·2024Open Access
Insulation between adjacent TADs is controlled by the width of their boundaries through distinct mechanisms
2024Open Access
Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics
2024Open Access
Segmentation algorithms and modeling of recurrent bursting events in neuronal and glial time series
arXiv (Cornell University)·2024Open Access
Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet, a Graph Reconstruction Algorithm Coupled to Image Processing
2024· 1 citedOpen Access
Voltage mapping in subcellular nanodomains using electro-diffusion modeling
The Journal of Chemical Physics·2024Open Access
Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels
Cell Reports·2024· 19 citedOpen Access
Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles
Nature Communications·2024· 13 citedOpen Access
EEG signatures at different propofol vs sevoflurane concentrations
2024· 3 citedOpen Access
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Frequent Co-authors

Z. Schuss(17), Nathalie Rouach(6), Jürgen Reingruber(6), Amit Singer(6), Eduard Korkotian(6), Assaf Amitai(5), Ulrike Pannasch(3), Pierre Parutto(3), Christian Giaume(2), Pascal Ezan(2), Dominik Freche(2), Andrew Seeber(2), Susan M. Gasser(2), Nathanaël Hozé(2), Antoine Triller(2), Marcus Fantham(2), Clemens F. Kaminski(2), Edward Avezov(2), Khanh Dao Duc(2), Menahem Segal(2)