Stacy Remiszewski

ALS Biopharma (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.5kcitations41works7.52yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(11), Protein Kinase Regulation and GTPase Signaling(7), Protein Degradation and Inhibitors(7), Synthetic Organic Chemistry Methods(5), Enzyme Structure and Function(4)

Publications41 total

Structural basis for sirtuin 2 activity and modulation: Current state and opportunities
Journal of Biological Chemistry·2025· 7 citedOpen Access
An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity
Antiviral Research·2024· 8 citedOpen Access
Inhibition of SIRT2 promotes death of human cytomegalovirus-infected peripheral blood monocytes via apoptosis and necroptosis
Antiviral Research·2023· 5 citedOpen Access
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
Journal of Clinical Investigation·2023· 24 citedOpen Access
Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis
Nature Cancer·2021· 69 citedOpen Access
Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain
Journal of Medicinal Chemistry·2013· 38 citedOpen Access
Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) Domain
Journal of Medicinal Chemistry·2013· 28 citedOpen Access
The structure of XIAP BIR2: understanding the selectivity of the BIR domains
Acta Crystallographica Section D Biological Crystallography·2013· 39 citedOpen Access
Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors
Journal of Medicinal Chemistry·2011· 63 citedOpen Access
Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo
Leukemia·2004· 59 cited
Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal
Cytotherapy·2004· 67 cited
Molecular and Cellular Basis for the Anti‐Proliferative Effects of the HDAC Inhibitor LAQ824
Novartis Foundation symposium·2004· 41 cited
Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.
PubMed·2004· 59 cited
Selective Growth Inhibition of Tumor Cells by a Novel Histone Deacetylase Inhibitor, NVP-LAQ824
Cancer Research·2004· 134 cited
The Discovery of NVP-LAQ824: From Concept to Clinic
Current Medicinal Chemistry·2003· 86 cited
<i>N</i>-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2<i>E</i>)-<i>N</i>-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1<i>H</i>-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)
Journal of Medicinal Chemistry·2003· 129 citedOpen Access
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
Blood·2003· 219 citedOpen Access
Psammaplins from the Sponge <i>Pseudoceratina </i><i>p</i><i>urpurea:</i> Inhibition of Both Histone Deacetylase and DNA Methyltransferase
The Journal of Organic Chemistry·2003· 307 cited
Evaluation of epigenetic therapies in early clinical trials: Development of novel pharmacodynamic endpoints
2003
Recent advances in the discovery of small molecule histone deacetylase inhibitors.
PubMed·2002· 34 cited
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Frequent Co-authors

Ronald J. Doll(11), Bancha Vibulbhan(10), Arthur G. Taveras(9), Peter Atadja(9), F. George Njoroge(8), Paul T. Kirschmeier(7), Alan K. Mallams(6), Viyyoor Girijavallabhan(6), Steven M. Weinreb(6), W. Robert Bishop(5), Lidia Sambucetti(5), Paul Kwon(5), David Cesarz(5), V. Girijavallabhan(5), A.K. Ganguly(5), Randall R. Rossman(5), Amin A. Nomeir(4), Kenneth W. Bair(4), Nancy Trogani(4), Mark E. Snow(4)