Jay R. Luly

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.4kcitations78works0.02yr avg
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Research Topics

Signaling Pathways in Disease(21), Chemical Synthesis and Analysis(13), Receptor Mechanisms and Signaling(8), Renin-Angiotensin System Studies(7), Bioactive Compounds and Antitumor Agents(7)

Publications78 total

2009 Chemistry Commencement Speaker
2009
Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 18 citedOpen Access
Rapamycin analogs with reduced systemic exposure
Bioorganic & Medicinal Chemistry Letters·2005· 28 citedOpen Access
Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor
Bioorganic & Medicinal Chemistry·2003· 45 cited
A Novel Antiinflammatory Maintains Glucocorticoid Efficacy with Reduced Side Effects
Molecular Endocrinology·2003· 221 cited
Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds
Journal of Biological Chemistry·2001· 99 citedOpen Access
Synthesis and Characterization of Non-Steroidal Ligands for the Glucocorticoid Receptor:  Selective Quinoline Derivatives with Prednisolone-Equivalent Functional Activity
Journal of Medicinal Chemistry·2001· 96 citedOpen Access
ChemInform Abstract: Synthesis of 4‐Substituted 4‐Arylpiperidines.
ChemInform·2001
Synthesis of 4-substituted 4-arylpiperidines
Tetrahedron Letters·2000· 12 cited
3,5-Bis(trifluoromethyl)pyrazoles:  A Novel Class of NFAT Transcription Factor Regulator
Journal of Medicinal Chemistry·2000· 120 cited
Retention of Immunosuppressant Activity in an Ascomycin Analogue Lacking a Hydrogen-Bonding Interaction with FKBP12
Journal of Medicinal Chemistry·1999· 6 citedOpen Access
Neointimal Formation After Balloon-Induced Vascular Injury in Yucatan Minipigs is Reduced by Oral Rapamycin
Journal of Cardiovascular Pharmacology·1999· 97 cited
A Macrolactam Inhibitor of T Helper Type 1 and T Helper Type 2 Cytokine Biosynthesis for Topical Treatment of Inflammatory Skin Diseases1
Journal of Investigative Dermatology·1999· 23 citedOpen Access
ChemInform Abstract: Synthesis and Immunosuppressant Activity of Pyrazole Carboxamides.
ChemInform·1999
Ex VivoAssessment of Immunosuppression in Undiluted Whole Blood from Pigs Dosed with Tacrolimus (FK506)
Clinical Immunology·1999· 3 cited
ChemInform Abstract: The Synthesis of (.+‐.)‐Wilforonide.
ChemInform·1998
Synthesis and immunosuppressant activity of pyrazole carboxamides
Bioorganic & Medicinal Chemistry Letters·1998· 21 cited
Discovery of Ascomycin Analogs with Potent Topical but Weak Systemic Activity for Treatment of Inflammatory Skin Diseases
Current Pharmaceutical Design·1998· 24 cited
ChemInform Abstract: Studies on an Immunosuppressive Macrolactam, Ascomycin: Synthesis of a C‐33 Hydroxyl Derivative.
ChemInform·1998
The Synthesis of (±)-Wilforonide
Synlett·1998· 4 cited
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Frequent Co-authors

Karl W. Mollison(17), George W. Carter(9), Gin C. Hsieh(9), Benjamin C. Lane(9), Thomas A. Fey(8), Jacob J. Plattner(7), Nwe Y. BaMaung(7), Herman H. Stein(7), Hollis D. Kleinert(7), Stephen W. Fesik(6), Megumi Kawai(6), Yat Sun Or(6), Henry Rapoport(5), Paul E. Wiedeman(5), Yung‐Wu Chen(5), Kennan C. Marsh(5), Michael P. Sheets(5), James M. Trevillyan(5), Thomas J. Perun(5), Ben Lane(4)