Thomas G. Hofmann

Johannes Gutenberg University Mainz — Germany

Medicine · Health Sciences

43h-index7.1kcitations109works4.82yr avg
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Research Topics

Cancer-related Molecular Pathways(34), Cell death mechanisms and regulation(22), DNA Repair Mechanisms(18), Retinoids in leukemia and cellular processes(13), Ubiquitin and proteasome pathways(12)

Publications108 total

Abstract 208: Epigenomic characterization of keratinocyte carcinomas in xeroderma pigmentosum
Cancer Research·2025
Double heterozygous pathogenic variants in BRCA2 and CHEK2 in a girl with adrenocortical carcinoma
Exploration of Endocrine and Metabolic Diseases·2025Open Access
Double Heterozygous Pathogenic Variants in TP53 and CHEK2 in Boy with Undifferentiated Embryonal Sarcoma of the Liver
International Journal of Molecular Sciences·2024· 1 citedOpen Access
The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence
Nucleic Acids Research·2024· 19 citedOpen Access
Puzzling phenomenon: adult-onset cancer predisposition and pediatric cancer
Trends in cancer·2024· 4 citedOpen Access
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
Journal of Advanced Research·2023· 17 citedOpen Access
Simultaneous <i>Nbs1</i> and <i>p53</i> inactivation in neural progenitors triggers high‐grade gliomas
Neuropathology and Applied Neurobiology·2023· 2 citedOpen Access
Supplementary Data, Figure S1 - S3 from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
2023Open Access
Data from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
2023Open Access
Supplementary Data, Figure S1 - S3 from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
2023Open Access
Data from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
2023Open Access
Data from Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2
2023Open Access
Data from Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2
2023Open Access
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
2023· 7 citedOpen Access
Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair
Nucleic Acids Research·2022· 13 citedOpen Access
p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
Cell Death and Disease·2022· 39 citedOpen Access
Regulating the p53 Tumor Suppressor Network at PML Biomolecular Condensates
Cancers·2022· 26 citedOpen Access
Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression
Cell Death and Disease·2022· 53 citedOpen Access
Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
Nature Communications·2022· 37 citedOpen Access
Dose response to methylating agents in the γH2AX, SCE and colony formation assays: Effect of MGMT and MPG overexpression
Mutation Research/Genetic Toxicology and Environmental Mutagenesis·2022Open Access
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Frequent Co-authors

M. Lienhard Schmitz(15), Wulf Dröge(13), Steffen P. Hehner(10), Hans Will(7), Carolina Glas(4), Andreas Möller(4), Magdalena C. Liebl(4), Dirk Sombroek(4), Nadja Bitomsky(4), Hüseyin Sirma(3), Andreas Dumont(3), Christoph Herbel(3), Eva Krieghoff‐Henning(3), Sonja Matt(2), Ilka Dauth(2), Jutta Moehlenbrink(2), Johanna Crone(2), Nicole Stollberg(2), Elisabeth Klimczak(2), Oliver Dienz(2)