Chris Chung‐Sing Chan

Hong Kong Science and Technology Parks Corporation — China

Medicine · Health Sciences

24h-index2.7kcitations50works1.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(27), COVID-19 Clinical Research Studies(20), Mosquito-borne diseases and control(6), Viral Infections and Vectors(6), Long-Term Effects of COVID-19(5)

Publications49 total

Structure-guided discovery of a small molecule inhibitor of SARS-CoV-2 main protease with potent <i>in vitro</i> and <i>in vivo</i> antiviral activities
Journal of Virology·2025· 1 citedOpen Access
P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation
Signal Transduction and Targeted Therapy·2023· 17 citedOpen Access
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking
Immunity·2023· 31 citedOpen Access
SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters <sup>1</sup>
Emerging Microbes & Infections·2023· 15 citedOpen Access
Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking
2023· 11 citedOpen Access
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo
Cell Reports Medicine·2022· 41 citedOpen Access
The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage
Emerging Microbes & Infections·2022· 16 citedOpen Access
Coronaviruses exploit a host cysteine-aspartic protease for replication
Nature·2022· 78 cited
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
Nature Communications·2022· 35 citedOpen Access
Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
Science·2022· 215 cited
Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Nature Communications·2022· 7 citedOpen Access
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Nature Communications·2022· 61 citedOpen Access
An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses
Science Translational Medicine·2022· 64 citedOpen Access
The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model
2022· 30 citedOpen Access
An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge
2022· 6 citedOpen Access
Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses
2021· 8 citedOpen Access
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury
Nature Communications·2021· 54 citedOpen Access
Emerging SARS-CoV-2 variants expand species tropism to murines
EBioMedicine·2021· 189 citedOpen Access
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Research Square (Research Square)·2021· 2 citedOpen Access
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
2021· 2 citedOpen Access
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Frequent Co-authors

Jasper Fuk‐Woo Chan(41), Vincent Kwok‐Man Poon(41), Kwok‐Yung Yuen(38), Shuofeng Yuan(33), Hin Chu(26), Jian‐Piao Cai(23), Jinxia Zhang(21), Kenn Ka‐Heng Chik(18), Chris Chun-Yiu Chan(17), Kelvin Kai‐Wang To(16), Jessica Oi‐Ling Tsang(12), Kwok‐Hung Chan(11), Cuiting Luo(10), Terrence Tsz‐Tai Yuen(10), Zhiwei Chen(9), Cyril Chik‐Yan Yip(8), Dong‐Yan Jin(8), Jie Zhou(8), Kaiming Tang(7), Siddharth Sridhar(7)