Paola Storici

Elettra-Sincrotrone Trieste S.C.p.A. — Italy

Computer Science · Physical Sciences

35h-index5.0kcitations105works1.52yr avg
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Research Topics

Computational Drug Discovery Methods(18), SARS-CoV-2 and COVID-19 Research(15), Microtubule and mitosis dynamics(12), Antimicrobial Peptides and Activities(12), Enzyme Structure and Function(12)

Publications105 total

ITABAG: Crystallographic investigations on macromolecules for a structure-based approach to One Health
European Synchrotron Radiation Facility·2026Open Access
Discovery of a new selective ERAP1 inhibitor for Hedgehog-dependent cancer treatment
Molecular Therapy·2025· 1 citedOpen Access
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies
European Journal of Medicinal Chemistry·2025Open Access
FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism
International Journal of Biological Macromolecules·2025· 3 citedOpen Access
Macromolecular crystallography at Elettra: current and future perspectives
Journal of Synchrotron Radiation·2025· 2 citedOpen Access
Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity
International Journal of Biological Macromolecules·2025· 6 citedOpen Access
Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2
ACS Pharmacology & Translational Science·2024Open Access
ULK1 inhibition for autophagy deregulation recovery
Acta Crystallographica Section A Foundations and Advances·2024Open Access
Structural biology at Elettra Sincrotrone – the present and the future
Acta Crystallographica Section A Foundations and Advances·2024
Protein targeting to glycogen (PTG), a validated target in Lafora disease
Acta Crystallographica Section A Foundations and Advances·2024Open Access
Probing conformational dynamics of EGFR mutants <i>via</i> SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design
Physical Chemistry Chemical Physics·2024· 5 citedOpen Access
Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV-2 Main Protease
Journal of Chemical Information and Modeling·2023· 12 citedOpen Access
Resolving the pharmacological redox-sensitivity of SARS-CoV-2 PLpro in drug repurposing screening enabled identification of the competitive GRL-0617 binding site inhibitor CPI-169
2023· 2 citedOpen Access
Identification of additional mechanistically important residues in the multidrug transporter styMdtM of <i>Salmonella</i> Typhi
Journal of Biomolecular Structure and Dynamics·2023
Unexpected single ligand occupancy and negative cooperativity in the SARS-CoV-2 Main protease
2023Open Access
Unexpected single ligand occupancy and negative cooperativity in the SARS-CoV-2 Main protease
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Unexpected single ligand occupancy and negative cooperativity in the SARS-CoV-2 Main protease
2023· 2 citedOpen Access
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
European Journal of Medicinal Chemistry·2023· 20 citedOpen Access
Data from PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
2023Open Access
Supplementary Fig. S1 from PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
2023Open Access
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Frequent Co-authors

Barbara Giabbai(9), Marta S. Semrau(7), Paolo Cappella(6), Tilman Schirmer(6), Elisa Costanzi(6), Nicola Demitri(6), Alessandro Tossi(6), Patrizia Carpinelli(5), Maria Laura Giorgini(5), Paola Vianello(5), Chiara Soncini(5), Enrico Pesenti(5), Daniele Fancelli(5), Andrea Mozzarelli(5), Marco Scocchi(5), Renato Gennaro(5), Margherita Zanetti(5), Valter Croci(4), Paola Zugnoni(4), Aurelio Marsiglio(4)