Gian Camenisch

Medicine · Health Sciences

29h-index3.1kcitations66works3.52yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(32), Pharmacogenetics and Drug Metabolism(21), Drug-Induced Hepatotoxicity and Protection(10), Computational Drug Discovery Methods(8), Pharmacological Effects and Toxicity Studies(7)

Publications66 total

Drug-induced cholestasis (DIC) predictions based on in vitro inhibition of major bile acid clearance mechanisms
Archives of Toxicology·2024· 3 cited
Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC)
Archives of Toxicology·2024· 4 cited
Fundamentals of Drug–Drug Interactions
2023
Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes
Toxicology in Vitro·2022· 29 cited
The Extended Clearance Model
2021· 2 cited
Double Trap Interface: A novel gas interface for high throughput analysis of biomedical samples by AMS
Drug Metabolism and Pharmacokinetics·2021· 7 citedOpen Access
Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism
Drug Metabolism and Disposition·2021· 6 citedOpen Access
Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite
Drug Metabolism and Disposition·2020· 68 citedOpen Access
An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data
Pharmacology Research & Perspectives·2020· 27 citedOpen Access
P174 - Absorption, distribution, metabolism, and excretion of tropifexor, a potent FXR agonist for the treatment of NASH, following a single oral 1 mg dose of [14C]tropifexor in healthy male subjects
Drug Metabolism and Pharmacokinetics·2020
Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes
Pulmonary Pharmacology & Therapeutics·2019· 10 cited
Examining P-gp efflux kinetics guided by the BDDCS – Rational selection of in vitro assay designs and mathematical models
European Journal of Pharmaceutical Sciences·2019· 12 cited
DILI_Camenisch_Supplementary Table_Final.xlsx
Figshare·2019Open Access
Drug-Induced Liver Injury Predictions: Extended Clearance Model and Its Use for Prospective Transporter and Enzyme-Based Hepatic Cell Stress Grading
International Journal of Pharmacy and Chemistry·2019· 3 citedOpen Access
Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)
Drug Metabolism Letters·2018· 29 citedOpen Access
Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
Drug Metabolism and Disposition·2018· 20 citedOpen Access
Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
Drug Metabolism and Disposition·2018· 54 citedOpen Access
Functional assessment of rat pulmonary flavin-containing monooxygenase activity
Xenobiotica·2018· 3 cited
Evaluation of cAMS for <sup>14</sup> C Microtracer ADME Studies: Opportunities to Change the Current Drug Development Paradigm
Bioanalysis·2018· 28 citedOpen Access
In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics
European Journal of Clinical Pharmacology·2017· 26 citedOpen Access
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Frequent Co-authors

Birk Poller(10), Jörg Huwyler(8), Markus Walles(8), Kenichi Umehara(7), Hilmar Schiller(7), H. Van De Waterbeemd(6), Gerd Folkers(6), Yi Jin(6), Annett Kunze(5), Ralph Woessner(5), Julia Riede(5), Felix Huth(5), Sébastien Bihorel(4), Ulrike Glaenzel(4), Hubert Borell(4), Michel Lemaire(3), Gerhard Groß(3), Axel Meißner(3), Jean‐Michel Scherrmann(3), Alexander D. James(3)