Simon Specklin

Centre National de la Recherche Scientifique — France

Chemistry · Physical Sciences

13h-index599citations43works2.62yr avg
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Research Topics

Click Chemistry and Applications(12), Fluorine in Organic Chemistry(8), Chemical Synthesis and Analysis(7), Radiopharmaceutical Chemistry and Applications(7), Synthetic Organic Chemistry Methods(7)

Publications43 total

New Phase Transfer Catalysts for Fluorine-18 Radiolabelling
Nuclear Medicine and Biology·2025
PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti–PD-L1 Immunotherapy and Targeted Therapy
Journal of Nuclear Medicine·2025· 2 citedOpen Access
Sydnonimines: synthesis, properties and applications in chemical biology
Chemical Communications·2025· 6 citedOpen Access
Author response for "A Cancer Immunoprofiling Strategy Using Mass Spectrometry Coupled with Bioorthogonal Cleavage"
2024
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study
Expert Opinion on Drug Delivery·2024· 3 cited
Imaging quantitative changes in blood-brain barrier permeability using [<sup>18</sup>F]2-fluoro-2-deoxy-sorbitol ([<sup>18</sup>F]FDS) PET in relation to glial cell recruitment in a mouse model of endotoxemia
Journal of Cerebral Blood Flow & Metabolism·2024· 3 citedOpen Access
A cancer immunoprofiling strategy using mass spectrometry coupled with bioorthogonal cleavage
Chemical Science·2024· 4 citedOpen Access
Impact of Radiolabeling Strategies on the Pharmacokinetics and Distribution of an Anti-PD-L1 PET Ligand
Molecular Pharmaceutics·2022· 8 cited
New phase transfer agents for fluorine 18 radiolabelling
Nuclear Medicine and Biology·2022
Pharmacokinetic preclinical evaluation of radioligation strategies impact on antibody fragment targeting PD-L1
Nuclear Medicine and Biology·2022
PET/Fluorescence Imaging: An Overview of the Chemical Strategies to Build Dual Imaging Tools
Bioconjugate Chemistry·2022· 50 cited
Original synthesis of radiolabeling precursors for batch and on resin one-step/late-stage radiofluorination of peptides
Chemical Communications·2020· 14 cited
Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide
Chemistry - A European Journal·2019· 6 cited
New fluorine-18 pretargeting PET imaging by bioorthogonal chlorosydnone–cycloalkyne click reaction
Chemical Communications·2019· 30 cited
[<sup>18</sup>F]FPyZIDE: A versatile prosthetic reagent for the fluorine‐18 radiolabeling of biologics via copper‐catalyzed or strain‐promoted alkyne‐azide cycloadditions
Journal of Labelled Compounds and Radiopharmaceuticals·2018· 9 cited
Fluorine-18 radiolabeling of biologics
Elsevier eBooks·2018· 4 cited
List of contributors
Elsevier eBooks·2018
Stereoselective Ring‐Opening of <i>gem</i>‐Difluorocyclopropanes: An Entry to Stereo‐defined (<i>E</i>,<i>E</i>)‐ and (<i>E</i>,<i>Z</i>)‐Conjugated Fluorodienes
Chemistry - A European Journal·2017· 21 cited
Copper-free sydnone-alkyne cycloaddition for the fluorine-18-radiolabeling of biologics
2017
Synthesis of the prosthetic group F-18 FPyMe for the radiolabeling of biologics via furan protection of the maleimide
Journal of Labelled Compounds and Radiopharmaceuticals·2017· 1 cited
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Frequent Co-authors

Bertrand Kühnast(14), Frédéric Taran(12), Jean‐Marc Weibel(10), Patrick Pale(10), Charles Truillet(7), Janine Cossy(7), Lucie Plougastel(6), Davide Audisio(6), Elodie Decuypère(5), Mylène Richard(5), Mélanie Roche(5), Sandra Gabillet(4), Philippe Bertus(4), Christophe Meyer(4), Dimitri Kereselidze(4), Fabien Caillé(4), Sergii Kolodych(3), Stefan Chassaing(3), Benoit Jégo(3), Geoffroy Sorin(3)