Gökhan S. Hotamışlıgil

Broad Institute — United States

Medicine · Health Sciences

112h-index93.0kcitations242works5.92yr avg
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Research Topics

Adipokines, Inflammation, and Metabolic Diseases(93), Adipose Tissue and Metabolism(91), Peroxisome Proliferator-Activated Receptors(49), Endoplasmic Reticulum Stress and Disease(47), Pancreatic function and diabetes(27)

Publications241 total

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
Cell Metabolism·2025Open Access
Author Correction: Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
Nature Medicine·2025Open Access
Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1
2025Open Access
Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH Pathogenesis
2025
CoQ imbalance drives reverse electron transport to disrupt liver metabolism
Nature·2025· 16 citedOpen Access
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research
Nature Metabolism·2025· 10 citedOpen Access
An organism-level quantitative flux model of energy metabolism in mice
Cell Metabolism·2025· 9 cited
FABP4 as a therapeutic host target controlling SARS-CoV-2 infection
EMBO Molecular Medicine·2025· 4 citedOpen Access
Transfer learning improves performance in volumetric electron microscopy organelle segmentation across tissues
Bioinformatics Advances·2024· 2 citedOpen Access
An adipo-pulmonary axis mediated by FABP4 hormone defines a target against obesity-induced airway disease
2024
Serum fatty-acid binding protein is associated with lung function in asthma
2024
Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway
2024· 1 citedOpen Access
An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease
2024Open Access
Endogenous p53 inhibitor TIRR dissociates systemic metabolic health from oncogenic activity
Cell Reports·2024· 3 citedOpen Access
Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity
Nature Communications·2024· 32 citedOpen Access
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression
Cell Metabolism·2024· 20 citedOpen Access
Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023
American Journal of Clinical Nutrition·2024· 12 citedOpen Access
FABP4 as a Therapeutic Host Target Controlling SARS-CoV2 Infection
2024· 1 citedOpen Access
An Organism-Level Quantitative Flux Model of Energy Metabolism in Mice
2024· 2 citedOpen Access
Author Correction: A central role for JNK in obesity and insulin resistance
Nature·2023· 7 citedOpen Access
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Frequent Co-authors

Cem Z. Görgün(10), Bruce M. Spiegelman(7), Masato Furuhashi(5), Gürol Tuncman(4), K. Teoman Uysal(4), Steven M. Watkins(4), Umut Özcan(3), Erkan Yılmaz(3), Margaret F. Gregor(3), Kazuhisa Maeda(3), Ling Yang(3), Ping Li(3), Suneng Fu(3), Haiming Cao(3), Barbara B. Kahn(3), Liza Makowski(3), Vladimir R. Babaev(3), Sergio Fazio(3), Rex A. Parker(3), Kathryn E. Wellen(2)