W Cools

Johnson & Johnson (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.9kcitations31works0.02yr avg
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Research Topics

Retinoids in leukemia and cellular processes(8), Antifungal resistance and susceptibility(6), Estrogen and related hormone effects(5), Microbial Natural Products and Biosynthesis(3), Advanced Proteomics Techniques and Applications(3)

Publications31 total

Identifying Metabolite Ions of Peptide Drugs in The Presence of An <i>In Vivo</i> Matrix Background
Bioanalysis·2012· 20 cited
Comparison of Triple Quadrupole And High-Resolution Tof-Ms For Quantification of Peptides
Bioanalysis·2012· 85 cited
A Canine Model to Evaluate Efficacy and Safety of γ-Secretase Inhibitors and Modulators
Journal of Alzheimer s Disease·2012· 17 cited
A Screening UHPLC–MS/MS Method for The Analysis of Amyloid Peptides in Cerebrospinal Fluid of Preclinical Species
Bioanalysis·2010· 26 cited
Synthesis and Biological Evaluation of 1,2,4-Triazinylphenylalkylthiazolecarboxylic Acid Esters as Cytokine-Inhibiting Antedrugs with Strong Bronchodilating Effects in an Animal Model of Asthma
Journal of Medicinal Chemistry·2004· 19 cited
Induction of the oxidative catabolism of retinoic acid in MCF-7 cells
British Journal of Cancer·1997· 16 citedOpen Access
Analysis of the oxidative catabolism of retinoic acid in rat Dunning R3327G prostate tumors
The Prostate·1996· 4 cited
Analysis of the oxidative catabolism of retinoic acid in rat Dunning R3327G prostate tumors
The Prostate·1996· 8 cited
Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid
Biochemical Pharmacology·1994· 36 cited
Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans
Antimicrobial Agents and Chemotherapy·1993· 101 citedOpen Access
Cytochrome P450-Dependent 14α-Demethylase
ACS symposium series·1992· 7 cited
Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells.
PubMed·1992· 83 cited
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.
Journal of Pharmacology and Experimental Therapeutics·1992· 101 cited
Suggested mechanism for the formation of 15-hydroxyeicosatrienoic acid by rat epidermal microsomes.
PubMed·1992· 3 cited
NADPH-dependent formation of 15- and 12-hydroxyeicosatrienoic acid from arachidonic acid by rat epidermal microsomes.
PubMed·1991· 18 cited
Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats.
Journal of Pharmacology and Experimental Therapeutics·1990· 136 cited
Comparative Effects of Ketoconazole on Rat, Dog and Human Testicular Steroidogenesis
Journal of enzyme inhibition·1989· 12 cited
Ketoconazole inhibits the in vitro and in vivo metabolism of all-trans-retinoic acid.
Journal of Pharmacology and Experimental Therapeutics·1988· 86 cited
Cytochrome p‐450: Target for itraconazole
Drug Development Research·1986· 94 cited
Cytochrome P-450 dependent steroid biosynthesis — targets for -substituted imidazoles and triazoles
Journal of Steroid Biochemistry·1986
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Frequent Co-authors

G. Willemsens(12), M C Coene(11), W. Lauwers(9), H. Van den Bossche(6), L. Le Jeune(6), Patrick Marichal(6), H. Vanden Bossche(6), Lieve Dillen(6), J. Goossens(5), Frans W. Cornelissen(4), J. Van Wauwe(4), G. Van Nyen(4), Walter Wouters(4), Carl Van Hove(4), Jean P. Van Wauwe(3), D. Bellens(3), R. De Coster(3), Liesbeth Vereyken(3), J. Gorrens(2), Hugo Verhoeven(2)