Melinda M. Mulvihill

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.1kcitations36works3.22yr avg
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Research Topics

Protein Degradation and Inhibitors(11), Ubiquitin and proteasome pathways(7), Cancer, Hypoxia, and Metabolism(5), Click Chemistry and Applications(5), Monoclonal and Polyclonal Antibodies Research(4)

Publications36 total

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
Cell chemical biology·2025· 1 cited
Correction to “Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-like KRAS G12C Inhibitors”
ACS Omega·2025Open Access
Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-Like KRAS G12C Inhibitors
ACS Omega·2024· 1 citedOpen Access
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
2024Open Access
Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
Covalent Library Screening by Targeted Mass Spectrometry for Rapid Binding Site Identification
Analytical Chemistry·2023· 8 cited
Small-Molecule Lead-Finding Trends across the Roche and Genentech Research Organizations
Journal of Medicinal Chemistry·2022· 22 cited
High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRAS<sup>G12C</sup> by Intact Protein MS and Targeted MRM
Analytical Chemistry·2022· 37 cited
A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands
Biochemistry·2022· 22 cited
Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein
Journal of the American Chemical Society·2021· 16 cited
Native Mass Spectrometry for the Study of PROTAC GNE‐987‐Containing Ternary Complexes
ChemMedChem·2021· 33 citedOpen Access
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
Journal of Medicinal Chemistry·2021· 159 cited
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties
Journal of Medicinal Chemistry·2021· 140 cited
Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables <i>in vivo</i> Activity (ChemMedChem 1/2020)
ChemMedChem·2020· 22 cited
Unlocking latent kinetic information from label-free binding
Scientific Reports·2019· 4 citedOpen Access
Antibody Conjugation of a Chimeric BET Degrader Enables <i>in vivo</i> Activity
ChemMedChem·2019· 178 cited
Quantitative Determination of Protein–Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry
Analytical Chemistry·2018· 62 cited
Determination of Affinity and Residence Time of Potent Drug-Target Complexes by Label-free Biosensing
Journal of Medicinal Chemistry·2018· 19 cited
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Molecular Cell·2018· 116 citedOpen Access
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer
ACS Chemical Biology·2015· 72 cited
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Frequent Co-authors

Daniel K. Nomura(12), Robert A. Blake(7), Tracy Kleinheinz(6), John G. Quinn(6), Sharon M. Louie(5), Gauri Deshmukh(5), Donglu Zhang(5), Peter S. Dragovich(5), Steven T. Staben(5), Wayne J. Fairbrother(5), Kunxin Luo(4), Thomas H. Pillow(4), Pragya Adhikari(4), Susan Kaufman(4), Katherine R. Kozak(4), Aimee O’Donohue(4), Rebecca K. Rowntree(4), Jack Sadowsky(4), John Wai(4), Zijin Xu(4)