Christine Wohlford-Lenane

University of Iowa — United States

Medicine · Health Sciences

36h-index9.7kcitations76works1.62yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(20), Neonatal Respiratory Health Research(20), COVID-19 Clinical Research Studies(15), Cystic Fibrosis Research Advances(10), Respiratory viral infections research(10)

Publications76 total

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling
EBioMedicine·2025· 1 citedOpen Access
Complement expression determines disease severity in mouse models of SARS-CoV-2 and influenza pneumonia
Immunobiology·2025· 1 citedOpen Access
Complement is primarily activated in the lung in a mouse model of severe COVID-19
iScience·2025· 5 citedOpen Access
IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo
2024Open Access
A predominately pulmonary activation of complement in a mouse model of severe COVID-19
2024Open Access
Adaptation of SARS-CoV-2 to ACE2 <sub>H353K</sub> mice reveals new spike residues that drive mouse infection
Journal of Virology·2024· 4 citedOpen Access
Complement is Primarily Activated in the Lung in a Severe COVID-19 Mouse Model
SSRN Electronic Journal·2024Open Access
Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo
Nature Communications·2023· 27 citedOpen Access
Interleukin 13–Induced Inflammation Increases DPP4 Abundance but Does Not Enhance Middle East Respiratory Syndrome Coronavirus Replication in Airway Epithelia
The Journal of Infectious Diseases·2023· 4 citedOpen Access
51 Activation of complement in a mouse model of severe COVID-19
Immunobiology·2023
Inter-individual Variation in Receptor Expression Influences MERS-CoV Infection and Immune Responses in Airway Epithelia
Frontiers in Public Health·2022· 5 citedOpen Access
620: Iterative screen identifies amphiphilic peptides that confer enhanced delivery of CRISPR-associated nucleases and adenine base editors to airway epithelia
Journal of Cystic Fibrosis·2021Open Access
Intersubject Variation in ACE2 Protein Expression in Human Airway Epithelia and Its Relationship to Severe Acute Respiratory Syndrome Coronavirus 2
The Journal of Infectious Diseases·2021· 4 citedOpen Access
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice
Nature·2020· 541 citedOpen Access
Rapid generation of a mouse model for Middle East respiratory syndrome
UNC Libraries·2020· 23 citedOpen Access
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
EBioMedicine·2020· 199 citedOpen Access
K18-hACE2 Mice for Studies of COVID-19 Treatments and Pathogenesis Including Anosmia
2020· 24 citedOpen Access
Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
2020· 36 citedOpen Access
Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection
mBio·2020· 57 citedOpen Access
Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
Nature Communications·2019· 116 citedOpen Access
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Frequent Co-authors

Paul B. McCray(35), David K. Meyerholz(19), Stanley Perlman(13), Alejandro A. Pezzulo(8), Michael J. Welsh(7), Joseph Zabner(7), Philip H. Karp(7), David A. Schwartz(7), David A. Stoltz(6), Dwight C. Look(5), Mariah Leidinger(5), Jeanne M. Snyder(5), Melissa A. Hickey(4), Lei Shi(4), Hong Peng Jia(4), Shyam Ramachandran(4), Lynda S. Ostedgaard(4), Miguel Ortiz(4), Jincun Zhao(4), Leah R. Reznikov(4)