Nicholas E. Propson

Baylor College of Medicine — United States

Neuroscience · Life Sciences

21h-index6.2kcitations35works10.22yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(16), Alzheimer's disease research and treatments(9), Cellular transport and secretion(6), Pluripotent Stem Cells Research(5), Lysosomal Storage Disorders Research(5)

Publications35 total

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease
Science Translational Medicine·2025· 1 cited
A Common PD-Risk <i>GBA1</i> Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction
2025Open Access
Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions
Cell Reports·2025· 5 citedOpen Access
LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome
Molecular Neurodegeneration·2025· 3 citedOpen Access
Reduction of neuronal activity mediated by blood-vessel regression in the adult brain
Nature Communications·2025· 8 citedOpen Access
GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction
2025· 1 cited
PILRA regulates microglial immunometabolism to reduce disease pathology as a candidate therapeutic target for Alzheimer’s disease
2025· 1 citedOpen Access
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
Cell·2024· 63 citedOpen Access
PILRA regulates microglial neuroinflammation and lipid metabolism as a candidate therapeutic target for Alzheimer’s disease
2024· 9 citedOpen Access
Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology
Journal of Clinical Investigation·2023· 58 citedOpen Access
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Nature Neuroscience·2023· 213 citedOpen Access
LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome
2022· 9 citedOpen Access
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease
Science Translational Medicine·2022· 233 cited
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
Immunity·2022· 211 citedOpen Access
Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques
2021Open Access
Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading
Proceedings of the National Academy of Sciences·2021· 162 citedOpen Access
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease
Science Translational Medicine·2020· 129 citedOpen Access
Complement in Neurologic Disease
Annual Review of Pathology Mechanisms of Disease·2020· 41 cited
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging
Journal of Clinical Investigation·2020· 229 citedOpen Access
Reduction of neuronal activity mediated by blood-vessel regression in the brain
2020· 9 citedOpen Access
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Frequent Co-authors

Hui Zheng(13), Sonnet S. Davis(11), Jung H. Suh(10), Gilbert Di Paolo(10), James A. Thomson(9), Zhonggang Hou(8), Joseph W. Lewcock(8), Shan V. Andrews(7), Ron Stewart(6), Ethan R. Roy(6), Rajarshi Ghosh(6), Annie Arguello(6), Hoang N. Nguyen(6), David Tatarakis(6), Connie Ha(6), Srijana Balasundar(6), Anastasia G. Henry(5), Kathryn M. Monroe(5), Wei Cao(4), Alexandra Litvinchuk(4)