Daniel P. Howrigan

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index31.7kcitations111works10.42yr avg
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Research Topics

Genomics and Rare Diseases(42), Genetic Associations and Epidemiology(38), Genomic variations and chromosomal abnormalities(33), Genetics and Neurodevelopmental Disorders(26), Attention Deficit Hyperactivity Disorder(8)

Publications104 total

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
2025· 2 citedOpen Access
Tutorial: guidelines for quality filtering of whole-exome and whole-genome sequencing data for population-scale association analyses
Nature Protocols·2025· 3 cited
A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner
2024· 10 citedOpen Access
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation
Nature Human Behaviour·2024· 13 citedOpen Access
Joint contributions of rare copy number variants and common SNPs to risk for schizophrenia
UNC Libraries·2024Open Access
Blended Genome Exome (BGE) as a Cost Efficient Alternative to Deep Whole Genomes or Arrays
2024· 11 citedOpen Access
Mapping and characterization of structural variation in 17,795 human genomes
UNC Libraries·2024Open Access
INSIGHTS FROM >80 LOCI ASSOCIATED WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
European Neuropsychopharmacology·2023
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals
Nature Communications·2023· 53 citedOpen Access
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions
Cell Genomics·2023· 37 citedOpen Access
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Nature Mental Health·2023· 206 citedOpen Access
Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Nature Genetics·2023· 12 citedOpen Access
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Nature Genetics·2023· 686 citedOpen Access
Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity
Scientific Reports·2023· 28 citedOpen Access
REPLACING GWAS ARRAYS: CAPTURING GENOMIC DIVERSITY WITH A NOVEL WHOLE-EXOME PLUS LOW-PASS WHOLE GENOME PRODUCT
European Neuropsychopharmacology·2022· 2 cited
CONTEXTUALIZING PSYCHIATRIC CONSTRUCTS AND THEIR RELATIONSHIPS TO PUBLIC HEALTH VIA BIOBANK-SCALE FACTOR ANALYSIS
European Neuropsychopharmacology·2022
EXOME SEQUENCING TECHNOLOGY AND ANALYSIS
European Neuropsychopharmacology·2022
Principled distillation of multidimensional UK Biobank data reveals insights into the correlated human phenome
2022· 4 citedOpen Access
Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes
Cell Genomics·2022· 277 citedOpen Access
A cross-disorder dosage sensitivity map of the human genome
Cell·2022· 342 citedOpen Access
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Frequent Co-authors

Benjamin M. Neale(36), Mark J. Daly(23), Felecia Cerrato(14), Duncan S. Palmer(13), Jacqueline I. Goldstein(12), Preben Bo Mortensen(12), Anders D. Børglum(12), Aarno Palotie(11), Esben Agerbo(11), Jonas Bybjerg‐Grauholm(11), Hailiang Huang(11), Jennifer L. Moran(11), Ole Mors(11), Timothy Poterba(11), Konrad J. Karczewski(10), Christine Stevens(10), Patrick F. Sullivan(10), Jakob Grove(10), Stephan Ripke(10), Ditte Demontis(10)